Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis?

Joint Authors

Södergren, Anna
Karp, Kjell
Bengtsson, Christine
Möller, Bozena
Rantapää-Dahlqvist, Solbritt
Wållberg-Jonsson, Solveig

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-10-04

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Objective.

Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease.

This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis (RA).

Methods.

Patients from northern Sweden diagnosed with early RA were consecutively recruited into an ongoing prospective study.

From these, all patients ≤60 years ( n = 71 ) were included for measurements of subclinical atherosclerosis at inclusion (T0) and five years later (T5).

Forty age- and sex-matched controls were included.

The patients were clinically assessed, SCORE, Reynolds Risk Score, and Larsen score were calculated, and blood samples were drawn from all individuals at T0 and T5.

Results.

There was no significant difference in the level of Lp-PLA2 between patients with RA and controls ( p > 0.05 ).

In simple linear regression models among patients with RA, Lp-PLA2 at T0 was significantly associated with intima media thickness (IMT) at T0 and T5, flow mediated dilation (FMD) at T0 and T5, ever smoking, male sex, HDL-cholesterol (inversely), non-HDL-cholesterol, SCORE, Reynolds Risk Score, and Larsen score ( p < 0.05 ).

Conclusion.

In this cohort of patients with early RA, the concentration of Lp-PLA2 was associated with both subclinical atherosclerosis and disease severity.

American Psychological Association (APA)

Södergren, Anna& Karp, Kjell& Bengtsson, Christine& Möller, Bozena& Rantapää-Dahlqvist, Solbritt& Wållberg-Jonsson, Solveig. 2015. Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis?. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056339

Modern Language Association (MLA)

Södergren, Anna…[et al.]. Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis?. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056339

American Medical Association (AMA)

Södergren, Anna& Karp, Kjell& Bengtsson, Christine& Möller, Bozena& Rantapää-Dahlqvist, Solbritt& Wållberg-Jonsson, Solveig. Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis?. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056339

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1056339