Mass Spectral Profile for Rapid Differentiating Beta-Lactams from Their Ring-Opened Impurities
المؤلفون المشاركون
Wang, Hecheng
Huang, Haiwei
Cao, Jin
Chui, Dehua
Xiao, Shengyuan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
High performance liquid chromatography tandem mass spectrometry (HPLC MS) has been widely used for β-lactam antibiotics determination.
However, its application to identify impurities of these frequently used drugs is not sufficient at present.
In this job, characteristic profiles of the collision induced dissociation (CID) spectra of both β-lactams and ring-opened β-lactams were extracted from the MS data of six β-lactam antibiotics and their forty-five impurities, and were confirmed by the MS data reported in the literature.
These characteristics have been successfully applied to rapid differentiation of β-lactam and ring-opened β-lactam impurities in cefixime, cefdinir, and cefaclor.
However, these characteristic profiles can only be obtained under low activating voltage.
They did not display in the high energy activated CID spectra.
Diagnostic fragmentations for determining the localization of double bond and substituents on the thiazine ring and the side chain were also observed.
In addition, several characteristic fragmentations are hopeful to be used to differentiate the configurations of C-2 on the thiazine ring of ring-opened impurities, which is generally disadvantageous of mass spectrometry.
Taken together, forty-five impurities were identified from the capsules of cefixime, cefdinir, and cefaclor.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Hecheng& Huang, Haiwei& Cao, Jin& Chui, Dehua& Xiao, Shengyuan. 2015. Mass Spectral Profile for Rapid Differentiating Beta-Lactams from Their Ring-Opened Impurities. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1056423
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Hecheng…[et al.]. Mass Spectral Profile for Rapid Differentiating Beta-Lactams from Their Ring-Opened Impurities. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1056423
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Hecheng& Huang, Haiwei& Cao, Jin& Chui, Dehua& Xiao, Shengyuan. Mass Spectral Profile for Rapid Differentiating Beta-Lactams from Their Ring-Opened Impurities. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1056423
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056423
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر