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The Cortisol Awakening Response in Patients with Poststroke Depression Is Blunted and Negatively Correlated with Depressive Mood
المؤلفون المشاركون
Kwon, Oh Jeong
Kim, Munsoo
Lee, Ho Sub
Sung, Kang-keyng
Lee, Sangkwan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
It is important to reduce poststroke depression (PSD) to improve the stroke outcomes and quality of life in stroke patients, but the underlying mechanisms of PSD are not completely understood.
As many studies implicate dysregulation of hypothalamic-pituitary-adrenal axis in the etiology of major depression and stroke, we compared the cortisol awakening response (CAR) of 28 admitted PSD patients with that of 23 age-matched caregiver controls.
Saliva samples for cortisol measurement were collected immediately, 15, 30, and 45 min after awakening for two consecutive days.
Depressive mood status in PSD patients was determined with Beck Depression Inventory and Hamilton Depression Rating Scale.
Salivary cortisol levels of PSD patients did not rise significantly at any sampling time, showing a somewhat flat curve.
Caregiver controls showed significantly higher CAR at 15 and 30 min after awakening compared to PSD patients even though the two groups did not differ at awakening or 45 min after awakening.
Area-under-the-curve analysis revealed a significant negative correlation between the CAR and the degree of depression in PSD patients.
Thus, our findings suggest that poststroke depression is closely related with dysfunctional HPA axis indicated by blunted CAR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kwon, Oh Jeong& Kim, Munsoo& Lee, Ho Sub& Sung, Kang-keyng& Lee, Sangkwan. 2015. The Cortisol Awakening Response in Patients with Poststroke Depression Is Blunted and Negatively Correlated with Depressive Mood. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056455
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kwon, Oh Jeong…[et al.]. The Cortisol Awakening Response in Patients with Poststroke Depression Is Blunted and Negatively Correlated with Depressive Mood. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056455
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kwon, Oh Jeong& Kim, Munsoo& Lee, Ho Sub& Sung, Kang-keyng& Lee, Sangkwan. The Cortisol Awakening Response in Patients with Poststroke Depression Is Blunted and Negatively Correlated with Depressive Mood. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056455
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056455
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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