The Cortisol Awakening Response in Patients with Poststroke Depression Is Blunted and Negatively Correlated with Depressive Mood
Joint Authors
Kwon, Oh Jeong
Kim, Munsoo
Lee, Ho Sub
Sung, Kang-keyng
Lee, Sangkwan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
It is important to reduce poststroke depression (PSD) to improve the stroke outcomes and quality of life in stroke patients, but the underlying mechanisms of PSD are not completely understood.
As many studies implicate dysregulation of hypothalamic-pituitary-adrenal axis in the etiology of major depression and stroke, we compared the cortisol awakening response (CAR) of 28 admitted PSD patients with that of 23 age-matched caregiver controls.
Saliva samples for cortisol measurement were collected immediately, 15, 30, and 45 min after awakening for two consecutive days.
Depressive mood status in PSD patients was determined with Beck Depression Inventory and Hamilton Depression Rating Scale.
Salivary cortisol levels of PSD patients did not rise significantly at any sampling time, showing a somewhat flat curve.
Caregiver controls showed significantly higher CAR at 15 and 30 min after awakening compared to PSD patients even though the two groups did not differ at awakening or 45 min after awakening.
Area-under-the-curve analysis revealed a significant negative correlation between the CAR and the degree of depression in PSD patients.
Thus, our findings suggest that poststroke depression is closely related with dysfunctional HPA axis indicated by blunted CAR.
American Psychological Association (APA)
Kwon, Oh Jeong& Kim, Munsoo& Lee, Ho Sub& Sung, Kang-keyng& Lee, Sangkwan. 2015. The Cortisol Awakening Response in Patients with Poststroke Depression Is Blunted and Negatively Correlated with Depressive Mood. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056455
Modern Language Association (MLA)
Kwon, Oh Jeong…[et al.]. The Cortisol Awakening Response in Patients with Poststroke Depression Is Blunted and Negatively Correlated with Depressive Mood. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056455
American Medical Association (AMA)
Kwon, Oh Jeong& Kim, Munsoo& Lee, Ho Sub& Sung, Kang-keyng& Lee, Sangkwan. The Cortisol Awakening Response in Patients with Poststroke Depression Is Blunted and Negatively Correlated with Depressive Mood. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056455