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Cooperative Regulation of Substrate Stiffness and Extracellular Matrix Proteins in Skin Wound Healing of Axolotls
المؤلفون المشاركون
Huang, Ting-Yu
Wu, Cheng-Han
Wang, Mu-Hui
Chen, Bo-Sung
Chiou, Ling-Ling
Lee, Hsuan-Shu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Urodele amphibians (Ambystoma mexicanum), unique among vertebrates, can regenerate appendages and other body parts entirely and functionally through a scar-free healing process.
The wound epithelium covering the amputated or damaged site forms early and is essential for initiating the subsequent regenerative steps.
However, the molecular mechanism through which the wound reepithelializes during regeneration remains unclear.
In this study, we developed an in vitro culture system that mimics an in vivo wound healing process; the biomechanical properties in the system were precisely defined and manipulated.
Skin explants that were cultured on 2 to 50 kPa collagen-coated substrates rapidly reepithelialized within 10 to 15 h; however, in harder (1 GPa) and other extracellular matrices (tenascin-, fibronectin-, and laminin-coated environments), the wound epithelium moved slowly.
Furthermore, the reepithelialization rate of skin explants from metamorphic axolotls cultured on a polystyrene plate (1 GPa) increased substantially.
These findings afford new insights and can facilitate investigating wound epithelium formation during early regeneration using biochemical and mechanical techniques.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Ting-Yu& Wu, Cheng-Han& Wang, Mu-Hui& Chen, Bo-Sung& Chiou, Ling-Ling& Lee, Hsuan-Shu. 2015. Cooperative Regulation of Substrate Stiffness and Extracellular Matrix Proteins in Skin Wound Healing of Axolotls. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056461
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Ting-Yu…[et al.]. Cooperative Regulation of Substrate Stiffness and Extracellular Matrix Proteins in Skin Wound Healing of Axolotls. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056461
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Ting-Yu& Wu, Cheng-Han& Wang, Mu-Hui& Chen, Bo-Sung& Chiou, Ling-Ling& Lee, Hsuan-Shu. Cooperative Regulation of Substrate Stiffness and Extracellular Matrix Proteins in Skin Wound Healing of Axolotls. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056461
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056461
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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