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Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model
المؤلفون المشاركون
Koskimäki, Janne
Tarkia, Miikka
Ahtola-Sätilä, Tuula
Saloranta, Lasse
Simola, Outi
Forsback, Ari-Pekka
Frantzén, Janek
Laakso, Aki
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Nimodipine is a widely used medication for treating delayed cerebral ischemia (DCI) after subarachnoid hemorrhage.
When administrated orally or intravenously, systemic hypotension is an undesirable side effect.
Intracranial subarachnoid delivery of nimodipine during aneurysm clipping may be more efficient way of preventing vasospasm and DCI due to higher concentration of nimodipine in cerebrospinal fluid (CSF).
The risk of systemic hypotension may also be decreased with intracranial delivery.
We used animal models to evaluate the feasibility of surgically implanting a silica-based nimodipine releasing implant into the subarachnoid space through a frontotemporal craniotomy.
Concentrations of released nimodipine were measured from plasma samples and CSF samples.
Implant degradation was followed using CT imaging.
After completing the recovery period, full histological examination was performed on the brain and meninges.
The in vitro characteristics of the implant were determined.
Our results show that the biodegradable silica-based implant can be used for an intracranial drug delivery system and no major histopathological foreign body reactions were observed.
CT imaging is a feasible method for determining the degradation of silica implants in vivo.
The sustained release profiles of nimodipine in CSF were achieved.
Compared to a traditional treatment, higher nimodipine CSF/plasma ratios can be obtained with the implant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Koskimäki, Janne& Tarkia, Miikka& Ahtola-Sätilä, Tuula& Saloranta, Lasse& Simola, Outi& Forsback, Ari-Pekka…[et al.]. 2015. Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056477
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Koskimäki, Janne…[et al.]. Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056477
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Koskimäki, Janne& Tarkia, Miikka& Ahtola-Sätilä, Tuula& Saloranta, Lasse& Simola, Outi& Forsback, Ari-Pekka…[et al.]. Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056477
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056477
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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