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Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model
Joint Authors
Koskimäki, Janne
Tarkia, Miikka
Ahtola-Sätilä, Tuula
Saloranta, Lasse
Simola, Outi
Forsback, Ari-Pekka
Frantzén, Janek
Laakso, Aki
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nimodipine is a widely used medication for treating delayed cerebral ischemia (DCI) after subarachnoid hemorrhage.
When administrated orally or intravenously, systemic hypotension is an undesirable side effect.
Intracranial subarachnoid delivery of nimodipine during aneurysm clipping may be more efficient way of preventing vasospasm and DCI due to higher concentration of nimodipine in cerebrospinal fluid (CSF).
The risk of systemic hypotension may also be decreased with intracranial delivery.
We used animal models to evaluate the feasibility of surgically implanting a silica-based nimodipine releasing implant into the subarachnoid space through a frontotemporal craniotomy.
Concentrations of released nimodipine were measured from plasma samples and CSF samples.
Implant degradation was followed using CT imaging.
After completing the recovery period, full histological examination was performed on the brain and meninges.
The in vitro characteristics of the implant were determined.
Our results show that the biodegradable silica-based implant can be used for an intracranial drug delivery system and no major histopathological foreign body reactions were observed.
CT imaging is a feasible method for determining the degradation of silica implants in vivo.
The sustained release profiles of nimodipine in CSF were achieved.
Compared to a traditional treatment, higher nimodipine CSF/plasma ratios can be obtained with the implant.
American Psychological Association (APA)
Koskimäki, Janne& Tarkia, Miikka& Ahtola-Sätilä, Tuula& Saloranta, Lasse& Simola, Outi& Forsback, Ari-Pekka…[et al.]. 2015. Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056477
Modern Language Association (MLA)
Koskimäki, Janne…[et al.]. Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056477
American Medical Association (AMA)
Koskimäki, Janne& Tarkia, Miikka& Ahtola-Sätilä, Tuula& Saloranta, Lasse& Simola, Outi& Forsback, Ari-Pekka…[et al.]. Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056477