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Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice
المؤلفون المشاركون
Langlois, Xavier
Ver Donck, Luc
Acton, Paul D.
Biesmans, Steven
De Haes, Patrick
Hellings, Niels
Bouwknecht, Jan A.
Nuydens, Rony
Davoodi, Nima
Meert, Theo F.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-28
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Clinical observations indicate that activation of the TNF-α system may contribute to the development of inflammation-associated depression.
Here, we tested the hypothesis that systemic upregulation of TNF-α induces neuroinflammation and behavioral changes relevant to depression.
We report that a single intraperitoneal injection of TNF-α in mice increased serum and brain levels of the proinflammatory mediators TNF-α, IL-6, and MCP-1, in a dose- and time-dependent manner, but not IL-1β.
Protein levels of the anti-inflammatory cytokine IL-10 increased in serum but not in the brain.
The transient release of immune molecules was followed by glial cell activation as indicated by increased astrocyte activation in bioluminescent Gfap-luc mice and elevated immunoreactivity against the microglial marker Iba1 in the dentate gyrus of TNF-α-challenged mice.
Additionally, TNF-α-injected mice were evaluated in a panel of behavioral tests commonly used to study sickness and depressive-like behavior in rodents.
Our behavioral data imply that systemic administration of TNF-α induces a strong sickness response characterized by reduced locomotor activity, decreased fluid intake, and body weight loss.
Depressive-like behavior could not be separated from sickness at any of the time points studied.
Together, these results demonstrate that peripheral TNF-α affects the central nervous system at a neuroimmune and behavioral level.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Biesmans, Steven& Bouwknecht, Jan A.& Ver Donck, Luc& Langlois, Xavier& Acton, Paul D.& De Haes, Patrick…[et al.]. 2015. Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1056480
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Biesmans, Steven…[et al.]. Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1056480
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Biesmans, Steven& Bouwknecht, Jan A.& Ver Donck, Luc& Langlois, Xavier& Acton, Paul D.& De Haes, Patrick…[et al.]. Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1056480
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056480
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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