Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice
Joint Authors
Langlois, Xavier
Ver Donck, Luc
Acton, Paul D.
Biesmans, Steven
De Haes, Patrick
Hellings, Niels
Bouwknecht, Jan A.
Nuydens, Rony
Davoodi, Nima
Meert, Theo F.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Clinical observations indicate that activation of the TNF-α system may contribute to the development of inflammation-associated depression.
Here, we tested the hypothesis that systemic upregulation of TNF-α induces neuroinflammation and behavioral changes relevant to depression.
We report that a single intraperitoneal injection of TNF-α in mice increased serum and brain levels of the proinflammatory mediators TNF-α, IL-6, and MCP-1, in a dose- and time-dependent manner, but not IL-1β.
Protein levels of the anti-inflammatory cytokine IL-10 increased in serum but not in the brain.
The transient release of immune molecules was followed by glial cell activation as indicated by increased astrocyte activation in bioluminescent Gfap-luc mice and elevated immunoreactivity against the microglial marker Iba1 in the dentate gyrus of TNF-α-challenged mice.
Additionally, TNF-α-injected mice were evaluated in a panel of behavioral tests commonly used to study sickness and depressive-like behavior in rodents.
Our behavioral data imply that systemic administration of TNF-α induces a strong sickness response characterized by reduced locomotor activity, decreased fluid intake, and body weight loss.
Depressive-like behavior could not be separated from sickness at any of the time points studied.
Together, these results demonstrate that peripheral TNF-α affects the central nervous system at a neuroimmune and behavioral level.
American Psychological Association (APA)
Biesmans, Steven& Bouwknecht, Jan A.& Ver Donck, Luc& Langlois, Xavier& Acton, Paul D.& De Haes, Patrick…[et al.]. 2015. Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1056480
Modern Language Association (MLA)
Biesmans, Steven…[et al.]. Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1056480
American Medical Association (AMA)
Biesmans, Steven& Bouwknecht, Jan A.& Ver Donck, Luc& Langlois, Xavier& Acton, Paul D.& De Haes, Patrick…[et al.]. Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1056480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056480