Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes
المؤلفون المشاركون
Caputo, Massimo
Cherif, Myriam
Nakaoka, Yoshikazu
Ghorbel, Mohamed T.
Angelini, Gianni D.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Gab1 (Grb2 associated binding protein 1) is a member of the scaffolding/docking proteins (Gab1, Gab2, and Gab3).
It is required for fibroblast cell survival and maintaining cardiac function.
Very little is known about human Gab1 expression in response to chronic hypoxia.
The present study examined the hypothesis that hypoxia regulates Gab1 expression in human paediatric myocardium and cultured rat cardiomyocytes.
Here we showed that Gab1 is expressed in myocardial tissue in acyanotic and cyanotic children with congenital heart defects.
Gab1 protein was upregulated in cyanotic compared to acyanotic hearts suggesting that Gab1 upregulation is a component of the survival program initiated by hypoxia in cyanotic children.
The expression of other Gab1 interacting partners was not affected by hypoxia and Gab1 regulation.
Additionally, using an in vitro model, we demonstrated that overexpressing Gab1 in neonatal cardiomyocytes, under hypoxic condition, resulted in the reduction of apoptosis suggesting a role for this protein in cardiomyocyte survival.
Altogether, our data provide strong evidence that Gab1 is important for heart cell survival following hypoxic stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cherif, Myriam& Caputo, Massimo& Nakaoka, Yoshikazu& Angelini, Gianni D.& Ghorbel, Mohamed T.. 2015. Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056487
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cherif, Myriam…[et al.]. Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056487
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cherif, Myriam& Caputo, Massimo& Nakaoka, Yoshikazu& Angelini, Gianni D.& Ghorbel, Mohamed T.. Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056487
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056487
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر