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Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes
Joint Authors
Caputo, Massimo
Cherif, Myriam
Nakaoka, Yoshikazu
Ghorbel, Mohamed T.
Angelini, Gianni D.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gab1 (Grb2 associated binding protein 1) is a member of the scaffolding/docking proteins (Gab1, Gab2, and Gab3).
It is required for fibroblast cell survival and maintaining cardiac function.
Very little is known about human Gab1 expression in response to chronic hypoxia.
The present study examined the hypothesis that hypoxia regulates Gab1 expression in human paediatric myocardium and cultured rat cardiomyocytes.
Here we showed that Gab1 is expressed in myocardial tissue in acyanotic and cyanotic children with congenital heart defects.
Gab1 protein was upregulated in cyanotic compared to acyanotic hearts suggesting that Gab1 upregulation is a component of the survival program initiated by hypoxia in cyanotic children.
The expression of other Gab1 interacting partners was not affected by hypoxia and Gab1 regulation.
Additionally, using an in vitro model, we demonstrated that overexpressing Gab1 in neonatal cardiomyocytes, under hypoxic condition, resulted in the reduction of apoptosis suggesting a role for this protein in cardiomyocyte survival.
Altogether, our data provide strong evidence that Gab1 is important for heart cell survival following hypoxic stress.
American Psychological Association (APA)
Cherif, Myriam& Caputo, Massimo& Nakaoka, Yoshikazu& Angelini, Gianni D.& Ghorbel, Mohamed T.. 2015. Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056487
Modern Language Association (MLA)
Cherif, Myriam…[et al.]. Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056487
American Medical Association (AMA)
Cherif, Myriam& Caputo, Massimo& Nakaoka, Yoshikazu& Angelini, Gianni D.& Ghorbel, Mohamed T.. Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056487