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Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma
المؤلفون المشاركون
De Falco, Giulia
Ambrosio, Maria Raffaella
Rocca, Bruno J.
Barone, Aurora
Onorati, Monica
Mundo, Lucia
Crivelli, Filippo
Di Nuovo, Franca
del Vecchio, Maria T.
Tripodi, Sergio A.
Tosi, Piero
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Translationally controlled tumor protein is a multifaceted protein involved in several physiological and biological functions.
Its expression in normal kidney and in renal carcinomas, once corroborated by functional data, may add elements to elucidate renal physiology and carcinogenesis.
In this study, translationally controlled tumor protein expression was evaluated by quantitative real time polymerase chain reaction and western blotting, and its localization was examined by immunohistochemistry on 84 nephrectomies for cancer.
In normal kidney protein expression was found in the cytoplasm of proximal and distal tubular cells, in cells of the thick segment of the loop of Henle, and in urothelial cells of the pelvis.
It was also detectable in cells of renal carcinoma with different pattern of localization (membranous and cytoplasmic) depending on tumor histotype.
Our data may suggest an involvement of translationally controlled tumor protein in normal physiology and carcinogenesis.
However, functional in vitro and in vivo studies are needed to verify this hypothesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ambrosio, Maria Raffaella& Rocca, Bruno J.& Barone, Aurora& Onorati, Monica& Mundo, Lucia& Crivelli, Filippo…[et al.]. 2015. Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056538
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ambrosio, Maria Raffaella…[et al.]. Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056538
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ambrosio, Maria Raffaella& Rocca, Bruno J.& Barone, Aurora& Onorati, Monica& Mundo, Lucia& Crivelli, Filippo…[et al.]. Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056538
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056538
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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