Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma
Joint Authors
De Falco, Giulia
Ambrosio, Maria Raffaella
Rocca, Bruno J.
Barone, Aurora
Onorati, Monica
Mundo, Lucia
Crivelli, Filippo
Di Nuovo, Franca
del Vecchio, Maria T.
Tripodi, Sergio A.
Tosi, Piero
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Translationally controlled tumor protein is a multifaceted protein involved in several physiological and biological functions.
Its expression in normal kidney and in renal carcinomas, once corroborated by functional data, may add elements to elucidate renal physiology and carcinogenesis.
In this study, translationally controlled tumor protein expression was evaluated by quantitative real time polymerase chain reaction and western blotting, and its localization was examined by immunohistochemistry on 84 nephrectomies for cancer.
In normal kidney protein expression was found in the cytoplasm of proximal and distal tubular cells, in cells of the thick segment of the loop of Henle, and in urothelial cells of the pelvis.
It was also detectable in cells of renal carcinoma with different pattern of localization (membranous and cytoplasmic) depending on tumor histotype.
Our data may suggest an involvement of translationally controlled tumor protein in normal physiology and carcinogenesis.
However, functional in vitro and in vivo studies are needed to verify this hypothesis.
American Psychological Association (APA)
Ambrosio, Maria Raffaella& Rocca, Bruno J.& Barone, Aurora& Onorati, Monica& Mundo, Lucia& Crivelli, Filippo…[et al.]. 2015. Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056538
Modern Language Association (MLA)
Ambrosio, Maria Raffaella…[et al.]. Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056538
American Medical Association (AMA)
Ambrosio, Maria Raffaella& Rocca, Bruno J.& Barone, Aurora& Onorati, Monica& Mundo, Lucia& Crivelli, Filippo…[et al.]. Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056538