Challenges in Using Circulating miRNAs as Cancer Biomarkers
المؤلفون المشاركون
Tiberio, Paola
Callari, Maurizio
Angeloni, Valentina
Daidone, Maria Grazia
Appierto, Valentina
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In the last years, circulating miRNAs have emerged as a new class of promising cancer biomarkers.
Independent studies have shown the feasibility of using these small RNAs as tools for the diagnosis and prognosis of different types of malignancies as well as for predicting and possibly monitoring treatment response.
However, despite an initial enthusiasm for their possible clinical application, widespread inconsistencies have been observed among the studies, and miRNA-based tools still represent the object of research within clinical diagnostic or treatment protocols.
The poor overlap of results could be explained, at least in part, by preanalytical and analytical variables and donor-related factors that could generate artefacts, impairing an accurate quantification of circulating miRNAs.
In fact, critical issues are represented by nonuniform sample choice, handling, and processing, as well as by blood cell contamination in sample preparation and lack of consensus for data normalization.
In this review, we address the potential technical biases and individual-related parameters that can influence circulating miRNA studies’ outcome.
The exciting potential of circulating miRNAs as cancer biomarkers could confer an important advance in the disease management, but their clinical significance might not be proven without a global consensus of procedures and standardized protocols for their accurate detection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tiberio, Paola& Callari, Maurizio& Angeloni, Valentina& Daidone, Maria Grazia& Appierto, Valentina. 2015. Challenges in Using Circulating miRNAs as Cancer Biomarkers. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056547
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tiberio, Paola…[et al.]. Challenges in Using Circulating miRNAs as Cancer Biomarkers. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056547
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tiberio, Paola& Callari, Maurizio& Angeloni, Valentina& Daidone, Maria Grazia& Appierto, Valentina. Challenges in Using Circulating miRNAs as Cancer Biomarkers. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056547
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056547
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر