Challenges in Using Circulating miRNAs as Cancer Biomarkers
Joint Authors
Tiberio, Paola
Callari, Maurizio
Angeloni, Valentina
Daidone, Maria Grazia
Appierto, Valentina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In the last years, circulating miRNAs have emerged as a new class of promising cancer biomarkers.
Independent studies have shown the feasibility of using these small RNAs as tools for the diagnosis and prognosis of different types of malignancies as well as for predicting and possibly monitoring treatment response.
However, despite an initial enthusiasm for their possible clinical application, widespread inconsistencies have been observed among the studies, and miRNA-based tools still represent the object of research within clinical diagnostic or treatment protocols.
The poor overlap of results could be explained, at least in part, by preanalytical and analytical variables and donor-related factors that could generate artefacts, impairing an accurate quantification of circulating miRNAs.
In fact, critical issues are represented by nonuniform sample choice, handling, and processing, as well as by blood cell contamination in sample preparation and lack of consensus for data normalization.
In this review, we address the potential technical biases and individual-related parameters that can influence circulating miRNA studies’ outcome.
The exciting potential of circulating miRNAs as cancer biomarkers could confer an important advance in the disease management, but their clinical significance might not be proven without a global consensus of procedures and standardized protocols for their accurate detection.
American Psychological Association (APA)
Tiberio, Paola& Callari, Maurizio& Angeloni, Valentina& Daidone, Maria Grazia& Appierto, Valentina. 2015. Challenges in Using Circulating miRNAs as Cancer Biomarkers. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056547
Modern Language Association (MLA)
Tiberio, Paola…[et al.]. Challenges in Using Circulating miRNAs as Cancer Biomarkers. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056547
American Medical Association (AMA)
Tiberio, Paola& Callari, Maurizio& Angeloni, Valentina& Daidone, Maria Grazia& Appierto, Valentina. Challenges in Using Circulating miRNAs as Cancer Biomarkers. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056547