Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts
المؤلفون المشاركون
Baumgart, Mario
Groth, Marco
Marthandan, Shiva
Priebe, Steffen
Cellerino, Alessandro
Guthke, Reinhard
Hemmerich, Peter
Diekmann, Stephan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-03
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Replicative senescence is of fundamental importance for the process of cellular aging, since it is a property of most of our somatic cells.
Here, we elucidated this process by comparing gene expression changes, measured by RNA-seq, in fibroblasts originating from two different tissues, embryonic lung (MRC-5) and foreskin (HFF), at five different time points during their transition into senescence.
Although the expression patterns of both fibroblast cell lines can be clearly distinguished, the similar differential expression of an ensemble of genes was found to correlate well with their transition into senescence, with only a minority of genes being cell line specific.
Clustering-based approaches further revealed common signatures between the cell lines.
Investigation of the mRNA expression levels at various time points during the lifespan of either of the fibroblasts resulted in a number of monotonically up- and downregulated genes which clearly showed a novel strong link to aging and senescence related processes which might be functional.
In terms of expression profiles of differentially expressed genes with age, common genes identified here have the potential to rule the transition into senescence of embryonic lung and foreskin fibroblasts irrespective of their different cellular origin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marthandan, Shiva& Priebe, Steffen& Baumgart, Mario& Groth, Marco& Cellerino, Alessandro& Guthke, Reinhard…[et al.]. 2015. Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056552
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marthandan, Shiva…[et al.]. Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1056552
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marthandan, Shiva& Priebe, Steffen& Baumgart, Mario& Groth, Marco& Cellerino, Alessandro& Guthke, Reinhard…[et al.]. Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056552
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056552
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر