The Diagnosis Value of Promoter Methylation of UCHL1 in the Serum for Progression of Gastric Cancer
المؤلفون المشاركون
Wang, Gongping
Zhang, Wei
Zhou, Bo
Jin, Canhui
Wang, Zengfang
Yang, Yantong
Wang, Zhenzhen
Chen, Ye
Feng, Xiaoshan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Aberrant promoter methylation has been considered as a potential molecular marker for gastric cancer (GC).
However, the role of methylation of FLNC, THBS1, and UCHL1 in the development and progression of GC has not been explored.
Methods.
The promoter methylation status of UCHL1, FLNC, THBS1, and DLEC1 was assessed by quantitative methylation-specific PCR (QMSP) in the serum of 82 GC patients, 46 chronic atrophic gastritis (CAG) subjects, and 40 healthy controls.
Results.
All four genes had significantly higher methylation levels in GC patients than in CAG and control subjects.
However, only UCHL1 methylation was significantly correlated with the tumor stage and lymph node metastasis.
While THBS1 methylation was altered in an age-dependent manner, FLNC methylation was correlated with differentiation and Helicobacter pylori infection.
DLEC1 methylation was only associated with tumor size.
Moreover, methylated UCHL1 with or without THBS1 in the serum was found to be significantly associated with a poor prognosis.
Conclusion.
The promoter methylation degree of FLNC, THBS1, UCHL1, and DLEC1 in serum could tell the existence of GC and only UCHL1 in the serum was also associated with poor prognosis of GC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Gongping& Zhang, Wei& Zhou, Bo& Jin, Canhui& Wang, Zengfang& Yang, Yantong…[et al.]. 2015. The Diagnosis Value of Promoter Methylation of UCHL1 in the Serum for Progression of Gastric Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056579
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Gongping…[et al.]. The Diagnosis Value of Promoter Methylation of UCHL1 in the Serum for Progression of Gastric Cancer. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056579
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Gongping& Zhang, Wei& Zhou, Bo& Jin, Canhui& Wang, Zengfang& Yang, Yantong…[et al.]. The Diagnosis Value of Promoter Methylation of UCHL1 in the Serum for Progression of Gastric Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056579
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056579
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر