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The Diagnosis Value of Promoter Methylation of UCHL1 in the Serum for Progression of Gastric Cancer
Joint Authors
Wang, Gongping
Zhang, Wei
Zhou, Bo
Jin, Canhui
Wang, Zengfang
Yang, Yantong
Wang, Zhenzhen
Chen, Ye
Feng, Xiaoshan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Aberrant promoter methylation has been considered as a potential molecular marker for gastric cancer (GC).
However, the role of methylation of FLNC, THBS1, and UCHL1 in the development and progression of GC has not been explored.
Methods.
The promoter methylation status of UCHL1, FLNC, THBS1, and DLEC1 was assessed by quantitative methylation-specific PCR (QMSP) in the serum of 82 GC patients, 46 chronic atrophic gastritis (CAG) subjects, and 40 healthy controls.
Results.
All four genes had significantly higher methylation levels in GC patients than in CAG and control subjects.
However, only UCHL1 methylation was significantly correlated with the tumor stage and lymph node metastasis.
While THBS1 methylation was altered in an age-dependent manner, FLNC methylation was correlated with differentiation and Helicobacter pylori infection.
DLEC1 methylation was only associated with tumor size.
Moreover, methylated UCHL1 with or without THBS1 in the serum was found to be significantly associated with a poor prognosis.
Conclusion.
The promoter methylation degree of FLNC, THBS1, UCHL1, and DLEC1 in serum could tell the existence of GC and only UCHL1 in the serum was also associated with poor prognosis of GC.
American Psychological Association (APA)
Wang, Gongping& Zhang, Wei& Zhou, Bo& Jin, Canhui& Wang, Zengfang& Yang, Yantong…[et al.]. 2015. The Diagnosis Value of Promoter Methylation of UCHL1 in the Serum for Progression of Gastric Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056579
Modern Language Association (MLA)
Wang, Gongping…[et al.]. The Diagnosis Value of Promoter Methylation of UCHL1 in the Serum for Progression of Gastric Cancer. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056579
American Medical Association (AMA)
Wang, Gongping& Zhang, Wei& Zhou, Bo& Jin, Canhui& Wang, Zengfang& Yang, Yantong…[et al.]. The Diagnosis Value of Promoter Methylation of UCHL1 in the Serum for Progression of Gastric Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056579