Placing Ion Channels into a Signaling Network of T Cells: From Maturing Thymocytes to Healthy T Lymphocytes or Leukemic T Lymphoblasts
المؤلفون المشاركون
Dobrovinskaya, Oxana
Delgado-Enciso, Iván
Quintero-Castro, Laura Johanna
Best-Aguilera, Carlos
Rojas-Sotelo, Rocío Monserrat
Pottosin, Igor
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-32، 32ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-19
دولة النشر
مصر
عدد الصفحات
32
التخصصات الرئيسية
الملخص EN
T leukemogenesis is a multistep process, where the genetic errors during T cell maturation cause the healthy progenitor to convert into the leukemic precursor that lost its ability to differentiate but possesses high potential for proliferation, self-renewal, and migration.
A new misdirecting “leukemogenic” signaling network appears, composed by three types of participants which are encoded by (1) genes implicated in determined stages of T cell development but deregulated by translocations or mutations, (2) genes which normally do not participate in T cell development but are upregulated, and (3) nondifferentially expressed genes which become highly interconnected with genes expressed differentially.
It appears that each of three groups may contain genes coding ion channels.
In T cells, ion channels are implicated in regulation of cell cycle progression, differentiation, activation, migration, and cell death.
In the present review we are going to reveal a relationship between different genetic defects, which drive the T cell neoplasias, with calcium signaling and ion channels.
We suggest that changes in regulation of various ion channels in different types of the T leukemias may provide the intracellular ion microenvironment favorable to maintain self-renewal capacity, arrest differentiation, induce proliferation, and enhance motility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dobrovinskaya, Oxana& Delgado-Enciso, Iván& Quintero-Castro, Laura Johanna& Best-Aguilera, Carlos& Rojas-Sotelo, Rocío Monserrat& Pottosin, Igor. 2015. Placing Ion Channels into a Signaling Network of T Cells: From Maturing Thymocytes to Healthy T Lymphocytes or Leukemic T Lymphoblasts. BioMed Research International،Vol. 2015, no. 2015, pp.1-32.
https://search.emarefa.net/detail/BIM-1056616
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dobrovinskaya, Oxana…[et al.]. Placing Ion Channels into a Signaling Network of T Cells: From Maturing Thymocytes to Healthy T Lymphocytes or Leukemic T Lymphoblasts. BioMed Research International No. 2015 (2015), pp.1-32.
https://search.emarefa.net/detail/BIM-1056616
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dobrovinskaya, Oxana& Delgado-Enciso, Iván& Quintero-Castro, Laura Johanna& Best-Aguilera, Carlos& Rojas-Sotelo, Rocío Monserrat& Pottosin, Igor. Placing Ion Channels into a Signaling Network of T Cells: From Maturing Thymocytes to Healthy T Lymphocytes or Leukemic T Lymphoblasts. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-32.
https://search.emarefa.net/detail/BIM-1056616
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056616
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر