Placing Ion Channels into a Signaling Network of T Cells: From Maturing Thymocytes to Healthy T Lymphocytes or Leukemic T Lymphoblasts
Joint Authors
Dobrovinskaya, Oxana
Delgado-Enciso, Iván
Quintero-Castro, Laura Johanna
Best-Aguilera, Carlos
Rojas-Sotelo, Rocío Monserrat
Pottosin, Igor
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-32, 32 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
32
Main Subjects
Abstract EN
T leukemogenesis is a multistep process, where the genetic errors during T cell maturation cause the healthy progenitor to convert into the leukemic precursor that lost its ability to differentiate but possesses high potential for proliferation, self-renewal, and migration.
A new misdirecting “leukemogenic” signaling network appears, composed by three types of participants which are encoded by (1) genes implicated in determined stages of T cell development but deregulated by translocations or mutations, (2) genes which normally do not participate in T cell development but are upregulated, and (3) nondifferentially expressed genes which become highly interconnected with genes expressed differentially.
It appears that each of three groups may contain genes coding ion channels.
In T cells, ion channels are implicated in regulation of cell cycle progression, differentiation, activation, migration, and cell death.
In the present review we are going to reveal a relationship between different genetic defects, which drive the T cell neoplasias, with calcium signaling and ion channels.
We suggest that changes in regulation of various ion channels in different types of the T leukemias may provide the intracellular ion microenvironment favorable to maintain self-renewal capacity, arrest differentiation, induce proliferation, and enhance motility.
American Psychological Association (APA)
Dobrovinskaya, Oxana& Delgado-Enciso, Iván& Quintero-Castro, Laura Johanna& Best-Aguilera, Carlos& Rojas-Sotelo, Rocío Monserrat& Pottosin, Igor. 2015. Placing Ion Channels into a Signaling Network of T Cells: From Maturing Thymocytes to Healthy T Lymphocytes or Leukemic T Lymphoblasts. BioMed Research International،Vol. 2015, no. 2015, pp.1-32.
https://search.emarefa.net/detail/BIM-1056616
Modern Language Association (MLA)
Dobrovinskaya, Oxana…[et al.]. Placing Ion Channels into a Signaling Network of T Cells: From Maturing Thymocytes to Healthy T Lymphocytes or Leukemic T Lymphoblasts. BioMed Research International No. 2015 (2015), pp.1-32.
https://search.emarefa.net/detail/BIM-1056616
American Medical Association (AMA)
Dobrovinskaya, Oxana& Delgado-Enciso, Iván& Quintero-Castro, Laura Johanna& Best-Aguilera, Carlos& Rojas-Sotelo, Rocío Monserrat& Pottosin, Igor. Placing Ion Channels into a Signaling Network of T Cells: From Maturing Thymocytes to Healthy T Lymphocytes or Leukemic T Lymphoblasts. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-32.
https://search.emarefa.net/detail/BIM-1056616
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056616