Simultaneous Treatment with Statins and Aspirin Reduces the Risk of Prostate Cancer Detection and Tumorigenic Properties in Prostate Cancer Cell Lines
المؤلفون المشاركون
Sequeiros, Tamara
Montes, Melania
Oliván, Mireia
Rigau, Marina
Colás, Eva
de Torres, Inés
Reventós, Jaume
Garcia, M.
Regis, L.
Celma, A.
Placer, J.
Doll, A.
Planas, Jacques
Morote, Juan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Nowadays prostate cancer is the most common solid tumor in men from industrialized countries and the second leading cause of death.
At the ages when PCa is usually diagnosed, mortality related to cardiovascular morbidity is high; therefore, men at risk for PCa frequently receive chronic lipid-lowering and antiplatelet treatment.
The aim of this study was to analyze how chronic treatment with statins, aspirin, and their combination influenced the risk of PCa detection.
The tumorigenic properties of these treatments were evaluated by proliferation, colony formation, invasion, and migration assays using different PCa cell lines, in order to assess how these treatments act at molecular level.
The results showed that a combination of statins and aspirin enhances the effect of individual treatments and seems to reduce the risk of PCa detection (OR: 0.616 (95% CI: 0.467–0.812), P<0.001).
However, if treatments are maintained, aspirin (OR: 1.835 (95% CI: 1.068–3.155), P=0.028) or the combination of both drugs (OR: 3.059 (95% CI: 1.894–4.939), P<0.001) represents an increased risk of HGPCa.
As observed at clinical level, these beneficial effects in vitro are enhanced when both treatments are administered simultaneously, suggesting that chronic, concomitant treatment with statins and aspirin has a protective effect on PCa incidence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oliván, Mireia& Rigau, Marina& Colás, Eva& Garcia, M.& Montes, Melania& Sequeiros, Tamara…[et al.]. 2015. Simultaneous Treatment with Statins and Aspirin Reduces the Risk of Prostate Cancer Detection and Tumorigenic Properties in Prostate Cancer Cell Lines. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056665
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oliván, Mireia…[et al.]. Simultaneous Treatment with Statins and Aspirin Reduces the Risk of Prostate Cancer Detection and Tumorigenic Properties in Prostate Cancer Cell Lines. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056665
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oliván, Mireia& Rigau, Marina& Colás, Eva& Garcia, M.& Montes, Melania& Sequeiros, Tamara…[et al.]. Simultaneous Treatment with Statins and Aspirin Reduces the Risk of Prostate Cancer Detection and Tumorigenic Properties in Prostate Cancer Cell Lines. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056665
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056665
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر