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Simultaneous Treatment with Statins and Aspirin Reduces the Risk of Prostate Cancer Detection and Tumorigenic Properties in Prostate Cancer Cell Lines
Joint Authors
Sequeiros, Tamara
Montes, Melania
Oliván, Mireia
Rigau, Marina
Colás, Eva
de Torres, Inés
Reventós, Jaume
Garcia, M.
Regis, L.
Celma, A.
Placer, J.
Doll, A.
Planas, Jacques
Morote, Juan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Nowadays prostate cancer is the most common solid tumor in men from industrialized countries and the second leading cause of death.
At the ages when PCa is usually diagnosed, mortality related to cardiovascular morbidity is high; therefore, men at risk for PCa frequently receive chronic lipid-lowering and antiplatelet treatment.
The aim of this study was to analyze how chronic treatment with statins, aspirin, and their combination influenced the risk of PCa detection.
The tumorigenic properties of these treatments were evaluated by proliferation, colony formation, invasion, and migration assays using different PCa cell lines, in order to assess how these treatments act at molecular level.
The results showed that a combination of statins and aspirin enhances the effect of individual treatments and seems to reduce the risk of PCa detection (OR: 0.616 (95% CI: 0.467–0.812), P<0.001).
However, if treatments are maintained, aspirin (OR: 1.835 (95% CI: 1.068–3.155), P=0.028) or the combination of both drugs (OR: 3.059 (95% CI: 1.894–4.939), P<0.001) represents an increased risk of HGPCa.
As observed at clinical level, these beneficial effects in vitro are enhanced when both treatments are administered simultaneously, suggesting that chronic, concomitant treatment with statins and aspirin has a protective effect on PCa incidence.
American Psychological Association (APA)
Oliván, Mireia& Rigau, Marina& Colás, Eva& Garcia, M.& Montes, Melania& Sequeiros, Tamara…[et al.]. 2015. Simultaneous Treatment with Statins and Aspirin Reduces the Risk of Prostate Cancer Detection and Tumorigenic Properties in Prostate Cancer Cell Lines. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056665
Modern Language Association (MLA)
Oliván, Mireia…[et al.]. Simultaneous Treatment with Statins and Aspirin Reduces the Risk of Prostate Cancer Detection and Tumorigenic Properties in Prostate Cancer Cell Lines. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056665
American Medical Association (AMA)
Oliván, Mireia& Rigau, Marina& Colás, Eva& Garcia, M.& Montes, Melania& Sequeiros, Tamara…[et al.]. Simultaneous Treatment with Statins and Aspirin Reduces the Risk of Prostate Cancer Detection and Tumorigenic Properties in Prostate Cancer Cell Lines. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056665