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Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain
المؤلفون المشاركون
Cosacak, Mehmet Ilyas
Papadimitriou, Christos
Kizil, Caghan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Regenerative capacity of the brain is a variable trait within animals.
Aquatic vertebrates such as zebrafish have widespread ability to renew their brains upon damage, while mammals have—if not none—very limited overall regenerative competence.
Underlying cause of such a disparity is not fully evident; however, one of the reasons could be activation of peculiar molecular programs, which might have specific roles after injury or damage, by the organisms that regenerate.
If this hypothesis is correct, then there must be genes and pathways that (a) are expressed only after injury or damage in tissues, (b) are biologically and functionally relevant to restoration of neural tissue, and (c) are not detected in regenerating organisms.
Presence of such programs might circumvent the initial detrimental effects of the damage and subsequently set up the stage for tissue redevelopment to take place by modulating the plasticity of the neural stem/progenitor cells.
Additionally, if transferable, those “molecular mechanisms of regeneration” could open up new avenues for regenerative therapies of humans in clinical settings.
This review focuses on the recent studies addressing injury/damage-induced molecular programs in zebrafish brain, underscoring the possibility of the presence of genes that could be used as biomarkers of neural plasticity and regeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cosacak, Mehmet Ilyas& Papadimitriou, Christos& Kizil, Caghan. 2015. Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056688
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cosacak, Mehmet Ilyas…[et al.]. Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056688
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cosacak, Mehmet Ilyas& Papadimitriou, Christos& Kizil, Caghan. Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056688
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056688
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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