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Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain
Joint Authors
Cosacak, Mehmet Ilyas
Papadimitriou, Christos
Kizil, Caghan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Regenerative capacity of the brain is a variable trait within animals.
Aquatic vertebrates such as zebrafish have widespread ability to renew their brains upon damage, while mammals have—if not none—very limited overall regenerative competence.
Underlying cause of such a disparity is not fully evident; however, one of the reasons could be activation of peculiar molecular programs, which might have specific roles after injury or damage, by the organisms that regenerate.
If this hypothesis is correct, then there must be genes and pathways that (a) are expressed only after injury or damage in tissues, (b) are biologically and functionally relevant to restoration of neural tissue, and (c) are not detected in regenerating organisms.
Presence of such programs might circumvent the initial detrimental effects of the damage and subsequently set up the stage for tissue redevelopment to take place by modulating the plasticity of the neural stem/progenitor cells.
Additionally, if transferable, those “molecular mechanisms of regeneration” could open up new avenues for regenerative therapies of humans in clinical settings.
This review focuses on the recent studies addressing injury/damage-induced molecular programs in zebrafish brain, underscoring the possibility of the presence of genes that could be used as biomarkers of neural plasticity and regeneration.
American Psychological Association (APA)
Cosacak, Mehmet Ilyas& Papadimitriou, Christos& Kizil, Caghan. 2015. Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056688
Modern Language Association (MLA)
Cosacak, Mehmet Ilyas…[et al.]. Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056688
American Medical Association (AMA)
Cosacak, Mehmet Ilyas& Papadimitriou, Christos& Kizil, Caghan. Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056688