Extramedullary Manifestation in Multiple Myeloma Bears High Incidence of Poor Cytogenetic Aberration and Novel Agents Resistance
المؤلفون المشاركون
Qu, Xiaoyan
Chen, Lijuan
Qiu, Hairong
Lu, Hua
Wu, Hanxin
Qiu, Hongxia
Liu, Peng
Guo, Rui
Li, Jianyong
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Extramedullary disease (EMD) in multiple myeloma (MM) patients is an uncommon event and more attention was directed toward the feature of these patients.
Cytogenetic aberration is an important characteristic of MM and is associated with patients’ outcome.
In this study, we aimed to compare the cytogenetic abnormality of patients with and without extramedullary manifestation, and to analyze the clinical outcomes of novel agents in EMD patients.
We retrospectively investigated data from 41 MM patients.
Our analyses showed del(17p13) in 31% of EMD versus 13% of medullary disease (P=0.03) and amp(1q21) in 55% versus 32% (P=0.019).
No differences were shown in del(13q14) and t(4;14).
24/27 patients with EMD at diagnosis responded to the novel agents-containing regimens.
However, when relapsed, 70% of patients did not benefit from the sequential use of novel agents as salvage therapy.
In 14 patients who developed EMD at relapse phase, only 2 patients responded to novel agents therapy.
Median overall survival of patients with extramedullary manifestations was 30 months, in comparison to 104 months for patients without EMD (P=0.002).
Patients with extramedullary manifestation bore high incidence of poor cytogenetic aberration and novel agents resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qu, Xiaoyan& Chen, Lijuan& Qiu, Hairong& Lu, Hua& Wu, Hanxin& Qiu, Hongxia…[et al.]. 2015. Extramedullary Manifestation in Multiple Myeloma Bears High Incidence of Poor Cytogenetic Aberration and Novel Agents Resistance. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056724
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qu, Xiaoyan…[et al.]. Extramedullary Manifestation in Multiple Myeloma Bears High Incidence of Poor Cytogenetic Aberration and Novel Agents Resistance. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056724
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qu, Xiaoyan& Chen, Lijuan& Qiu, Hairong& Lu, Hua& Wu, Hanxin& Qiu, Hongxia…[et al.]. Extramedullary Manifestation in Multiple Myeloma Bears High Incidence of Poor Cytogenetic Aberration and Novel Agents Resistance. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056724
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056724
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر