Extramedullary Manifestation in Multiple Myeloma Bears High Incidence of Poor Cytogenetic Aberration and Novel Agents Resistance
Joint Authors
Qu, Xiaoyan
Chen, Lijuan
Qiu, Hairong
Lu, Hua
Wu, Hanxin
Qiu, Hongxia
Liu, Peng
Guo, Rui
Li, Jianyong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Extramedullary disease (EMD) in multiple myeloma (MM) patients is an uncommon event and more attention was directed toward the feature of these patients.
Cytogenetic aberration is an important characteristic of MM and is associated with patients’ outcome.
In this study, we aimed to compare the cytogenetic abnormality of patients with and without extramedullary manifestation, and to analyze the clinical outcomes of novel agents in EMD patients.
We retrospectively investigated data from 41 MM patients.
Our analyses showed del(17p13) in 31% of EMD versus 13% of medullary disease (P=0.03) and amp(1q21) in 55% versus 32% (P=0.019).
No differences were shown in del(13q14) and t(4;14).
24/27 patients with EMD at diagnosis responded to the novel agents-containing regimens.
However, when relapsed, 70% of patients did not benefit from the sequential use of novel agents as salvage therapy.
In 14 patients who developed EMD at relapse phase, only 2 patients responded to novel agents therapy.
Median overall survival of patients with extramedullary manifestations was 30 months, in comparison to 104 months for patients without EMD (P=0.002).
Patients with extramedullary manifestation bore high incidence of poor cytogenetic aberration and novel agents resistance.
American Psychological Association (APA)
Qu, Xiaoyan& Chen, Lijuan& Qiu, Hairong& Lu, Hua& Wu, Hanxin& Qiu, Hongxia…[et al.]. 2015. Extramedullary Manifestation in Multiple Myeloma Bears High Incidence of Poor Cytogenetic Aberration and Novel Agents Resistance. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056724
Modern Language Association (MLA)
Qu, Xiaoyan…[et al.]. Extramedullary Manifestation in Multiple Myeloma Bears High Incidence of Poor Cytogenetic Aberration and Novel Agents Resistance. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056724
American Medical Association (AMA)
Qu, Xiaoyan& Chen, Lijuan& Qiu, Hairong& Lu, Hua& Wu, Hanxin& Qiu, Hongxia…[et al.]. Extramedullary Manifestation in Multiple Myeloma Bears High Incidence of Poor Cytogenetic Aberration and Novel Agents Resistance. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056724