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A Comparative Evaluation of a Novel Vaccine in APPPS1 Mouse Models of Alzheimer’s Disease
المؤلفون المشاركون
Lombardi, Valter R. M.
Lakshmana, Madepalli Krishnappa
Vigo, Carmen
Cacabelos, Ramón
Fernández-Novoa, Lucía
Etcheverría, Ignacio
Carrera, Iván
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-11
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Immunization against amyloid-beta-peptide (Aβ) has been widely investigated as a potential immunotherapeutic approach for Alzheimer’s disease (AD).
With the aim of developing an active immunogenic vaccine without need of coadjuvant modification for human trials and therefore avoiding such side effects, we designed the Aβ1–42 vaccine (EB101), delivered in a liposomal matrix, that based on our previous studies significantly prevents and reverses the AD neuropathology, clearing Aβ plaques while markedly reducing neuronal degeneration, behavioral deficits, and minimizing neuroinflammation in APP/PS1 transgenic mice.
Here, the efficacy of our immunogenic vaccine EB101 was compared with the original immunization vaccine cocktail Aβ42 + CFA/IFA (Freund’s adjuvant), in order to characterize the effect of sphingosine-1-phosphate (S1P) in the immunotherapeutic response.
Quantitative analysis of amyloid burden showed a notable decrease in the neuroinflammation reaction against Aβ plaques when S1P was compared with other treatments, suggesting that S1P plays a key role as a neuroprotective agent.
Moreover, EB101 immunized mice presented a protective immunogenic reaction resulting in the increase of Aβ-specific antibody response and decrease of reactive glia in the affected brain areas, leading to a Th2 immunological reaction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carrera, Iván& Etcheverría, Ignacio& Fernández-Novoa, Lucía& Lombardi, Valter R. M.& Lakshmana, Madepalli Krishnappa& Cacabelos, Ramón…[et al.]. 2015. A Comparative Evaluation of a Novel Vaccine in APPPS1 Mouse Models of Alzheimer’s Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1056797
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carrera, Iván…[et al.]. A Comparative Evaluation of a Novel Vaccine in APPPS1 Mouse Models of Alzheimer’s Disease. BioMed Research International No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1056797
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carrera, Iván& Etcheverría, Ignacio& Fernández-Novoa, Lucía& Lombardi, Valter R. M.& Lakshmana, Madepalli Krishnappa& Cacabelos, Ramón…[et al.]. A Comparative Evaluation of a Novel Vaccine in APPPS1 Mouse Models of Alzheimer’s Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1056797
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056797
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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