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A Comparative Evaluation of a Novel Vaccine in APPPS1 Mouse Models of Alzheimer’s Disease
Joint Authors
Lombardi, Valter R. M.
Lakshmana, Madepalli Krishnappa
Vigo, Carmen
Cacabelos, Ramón
Fernández-Novoa, Lucía
Etcheverría, Ignacio
Carrera, Iván
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-11
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Immunization against amyloid-beta-peptide (Aβ) has been widely investigated as a potential immunotherapeutic approach for Alzheimer’s disease (AD).
With the aim of developing an active immunogenic vaccine without need of coadjuvant modification for human trials and therefore avoiding such side effects, we designed the Aβ1–42 vaccine (EB101), delivered in a liposomal matrix, that based on our previous studies significantly prevents and reverses the AD neuropathology, clearing Aβ plaques while markedly reducing neuronal degeneration, behavioral deficits, and minimizing neuroinflammation in APP/PS1 transgenic mice.
Here, the efficacy of our immunogenic vaccine EB101 was compared with the original immunization vaccine cocktail Aβ42 + CFA/IFA (Freund’s adjuvant), in order to characterize the effect of sphingosine-1-phosphate (S1P) in the immunotherapeutic response.
Quantitative analysis of amyloid burden showed a notable decrease in the neuroinflammation reaction against Aβ plaques when S1P was compared with other treatments, suggesting that S1P plays a key role as a neuroprotective agent.
Moreover, EB101 immunized mice presented a protective immunogenic reaction resulting in the increase of Aβ-specific antibody response and decrease of reactive glia in the affected brain areas, leading to a Th2 immunological reaction.
American Psychological Association (APA)
Carrera, Iván& Etcheverría, Ignacio& Fernández-Novoa, Lucía& Lombardi, Valter R. M.& Lakshmana, Madepalli Krishnappa& Cacabelos, Ramón…[et al.]. 2015. A Comparative Evaluation of a Novel Vaccine in APPPS1 Mouse Models of Alzheimer’s Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1056797
Modern Language Association (MLA)
Carrera, Iván…[et al.]. A Comparative Evaluation of a Novel Vaccine in APPPS1 Mouse Models of Alzheimer’s Disease. BioMed Research International No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1056797
American Medical Association (AMA)
Carrera, Iván& Etcheverría, Ignacio& Fernández-Novoa, Lucía& Lombardi, Valter R. M.& Lakshmana, Madepalli Krishnappa& Cacabelos, Ramón…[et al.]. A Comparative Evaluation of a Novel Vaccine in APPPS1 Mouse Models of Alzheimer’s Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1056797
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056797