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Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood-Brain Barrier
المؤلفون المشاركون
Opatrilova, Radka
Zaruba, Kamil
Oravec, Michal
Kunes, Martin
Ulbrich, Pavel
Brezaniova, Ingrid
Triska, Jan
Babula, Petr
Jampilek, Josef
Suchý, Pavel
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The blood-brain barrier prevents the passage of many drugs that target the central nervous system.
This paper presents the preparation and characterization of silica-based nanocarriers loaded with piracetam, pentoxifylline, and pyridoxine (drugs from the class of nootropics), which are designed to enhance the permeation of the drugs from the circulatory system through the blood-brain barrier.
Their permeation was compared with non-nanoparticle drug substances (bulk materials) by means of an in vivo model of rat brain perfusion.
The size and morphology of the nanoparticles were characterized by transmission electron microscopy.
The content of the drug substances in silica-based nanocarriers was analysed by elemental analysis and UV spectrometry.
Microscopic analysis of visualized silica nanocarriers in the perfused brain tissue was performed.
The concentration of the drug substances in the tissue was determined by means of UHPLC-DAD/HRMS LTQ Orbitrap XL.
It was found that the drug substances in silica-based nanocarriers permeated through the blood brain barrier to the brain tissue, whereas bulk materials were not detected in the brain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jampilek, Josef& Zaruba, Kamil& Oravec, Michal& Kunes, Martin& Babula, Petr& Ulbrich, Pavel…[et al.]. 2015. Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood-Brain Barrier. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056821
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jampilek, Josef…[et al.]. Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood-Brain Barrier. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056821
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jampilek, Josef& Zaruba, Kamil& Oravec, Michal& Kunes, Martin& Babula, Petr& Ulbrich, Pavel…[et al.]. Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood-Brain Barrier. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056821
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056821
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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