Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood-Brain Barrier
Joint Authors
Opatrilova, Radka
Zaruba, Kamil
Oravec, Michal
Kunes, Martin
Ulbrich, Pavel
Brezaniova, Ingrid
Triska, Jan
Babula, Petr
Jampilek, Josef
Suchý, Pavel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The blood-brain barrier prevents the passage of many drugs that target the central nervous system.
This paper presents the preparation and characterization of silica-based nanocarriers loaded with piracetam, pentoxifylline, and pyridoxine (drugs from the class of nootropics), which are designed to enhance the permeation of the drugs from the circulatory system through the blood-brain barrier.
Their permeation was compared with non-nanoparticle drug substances (bulk materials) by means of an in vivo model of rat brain perfusion.
The size and morphology of the nanoparticles were characterized by transmission electron microscopy.
The content of the drug substances in silica-based nanocarriers was analysed by elemental analysis and UV spectrometry.
Microscopic analysis of visualized silica nanocarriers in the perfused brain tissue was performed.
The concentration of the drug substances in the tissue was determined by means of UHPLC-DAD/HRMS LTQ Orbitrap XL.
It was found that the drug substances in silica-based nanocarriers permeated through the blood brain barrier to the brain tissue, whereas bulk materials were not detected in the brain.
American Psychological Association (APA)
Jampilek, Josef& Zaruba, Kamil& Oravec, Michal& Kunes, Martin& Babula, Petr& Ulbrich, Pavel…[et al.]. 2015. Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood-Brain Barrier. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056821
Modern Language Association (MLA)
Jampilek, Josef…[et al.]. Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood-Brain Barrier. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056821
American Medical Association (AMA)
Jampilek, Josef& Zaruba, Kamil& Oravec, Michal& Kunes, Martin& Babula, Petr& Ulbrich, Pavel…[et al.]. Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood-Brain Barrier. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056821