Gold Nanotheranostics: Photothermal Therapy and Imaging of Mucin 7 Conjugated Antibody Nanoparticles for Urothelial Cancer
المؤلفون المشاركون
Chen, Chieh Hsiao
Wu, Yi-Jhen
Chen, Jia-Jin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To kill urothelial cancer cells while preserving healthy cells, this study used photothermal therapy (PTT).
PTT techniques target urothelial cancer cells using gold nanoparticles (GNPs) and a green light laser.
Materials and Methods.
The GNPs were conjugated with anti-Mucin 7 antibodies, which acted as a probe for targeting tumor cells.
Conjugated GNPs were exposed to a green light laser (532 nm) with sufficient thermal energy to kill the transitional cell carcinomas (TCCs).
Results.
According to our results, nanoparticles conjugated with Mucin 7 antibodies damaged all types of cancer cells (MBT2, T24, 9202, and 8301) at relatively low energy levels (i.e., 500 laser shots at 10 W/cm2 in power, 1.6 Hz in frequency, and 300 ms in duration).
Nonconjugated nanoparticles required 30 W/cm2 or more to achieve the same effect.
Cell damage was directly related to irradiation time and applied laser energy.
Conclusions.
The minimally invasive PTT procedure combined with Mucin 7 targeted GNPs is able to kill cancer cells and preserve healthy cells.
The success of this treatment technique can likely be attributed to the lower amount of energy required to kill targeted cancer cells compared with that required to kill nontargeted cancer cells.
Our in vitro pilot study yielded promising results; however, additional animal studies are required to confirm these findings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Chieh Hsiao& Wu, Yi-Jhen& Chen, Jia-Jin. 2015. Gold Nanotheranostics: Photothermal Therapy and Imaging of Mucin 7 Conjugated Antibody Nanoparticles for Urothelial Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056828
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Chieh Hsiao…[et al.]. Gold Nanotheranostics: Photothermal Therapy and Imaging of Mucin 7 Conjugated Antibody Nanoparticles for Urothelial Cancer. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056828
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Chieh Hsiao& Wu, Yi-Jhen& Chen, Jia-Jin. Gold Nanotheranostics: Photothermal Therapy and Imaging of Mucin 7 Conjugated Antibody Nanoparticles for Urothelial Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056828
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056828
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر