Gold Nanotheranostics: Photothermal Therapy and Imaging of Mucin 7 Conjugated Antibody Nanoparticles for Urothelial Cancer
Joint Authors
Chen, Chieh Hsiao
Wu, Yi-Jhen
Chen, Jia-Jin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To kill urothelial cancer cells while preserving healthy cells, this study used photothermal therapy (PTT).
PTT techniques target urothelial cancer cells using gold nanoparticles (GNPs) and a green light laser.
Materials and Methods.
The GNPs were conjugated with anti-Mucin 7 antibodies, which acted as a probe for targeting tumor cells.
Conjugated GNPs were exposed to a green light laser (532 nm) with sufficient thermal energy to kill the transitional cell carcinomas (TCCs).
Results.
According to our results, nanoparticles conjugated with Mucin 7 antibodies damaged all types of cancer cells (MBT2, T24, 9202, and 8301) at relatively low energy levels (i.e., 500 laser shots at 10 W/cm2 in power, 1.6 Hz in frequency, and 300 ms in duration).
Nonconjugated nanoparticles required 30 W/cm2 or more to achieve the same effect.
Cell damage was directly related to irradiation time and applied laser energy.
Conclusions.
The minimally invasive PTT procedure combined with Mucin 7 targeted GNPs is able to kill cancer cells and preserve healthy cells.
The success of this treatment technique can likely be attributed to the lower amount of energy required to kill targeted cancer cells compared with that required to kill nontargeted cancer cells.
Our in vitro pilot study yielded promising results; however, additional animal studies are required to confirm these findings.
American Psychological Association (APA)
Chen, Chieh Hsiao& Wu, Yi-Jhen& Chen, Jia-Jin. 2015. Gold Nanotheranostics: Photothermal Therapy and Imaging of Mucin 7 Conjugated Antibody Nanoparticles for Urothelial Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056828
Modern Language Association (MLA)
Chen, Chieh Hsiao…[et al.]. Gold Nanotheranostics: Photothermal Therapy and Imaging of Mucin 7 Conjugated Antibody Nanoparticles for Urothelial Cancer. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056828
American Medical Association (AMA)
Chen, Chieh Hsiao& Wu, Yi-Jhen& Chen, Jia-Jin. Gold Nanotheranostics: Photothermal Therapy and Imaging of Mucin 7 Conjugated Antibody Nanoparticles for Urothelial Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056828