Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review
المؤلفون المشاركون
Venkatesan, Ramu
Ji, Eunhee
Kim, Sun Yeou
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-22، 22ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-14
دولة النشر
مصر
عدد الصفحات
22
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD), characterized by progressive dementia and deterioration of cognitive function, is an unsolved social and medical problem.
Age, nutrition, and toxins are the most common causes of AD.
However, currently no credible treatment is available for AD.
Traditional herbs and phytochemicals may delay its onset and slow its progression and also allow recovery by targeting multiple pathological causes by antioxidative, anti-inflammatory, and antiamyloidogenic properties.
They also regulate mitochondrial stress, apoptotic factors, free radical scavenging system, and neurotrophic factors.
Neurotrophins such as BDNF, NGF, NT3, and NT4/5 play a vital role in neuronal and nonneuronal responses to AD.
Neurotrophins depletion accelerates the progression of AD and therefore, replacing such neurotrophins may be a potential treatment for neurodegenerative disease.
Here, we review the phytochemicals that mediate the signaling pathways involved in neuroprotection specifically neurotrophin-mediated activation of Trk receptors and members of p75NTR superfamily.
We focus on representative phenolic derivatives, iridoid glycosides, terpenoids, alkaloids, and steroidal saponins as regulators of neurotrophin-mediated neuroprotection.
Although these phytochemicals have attracted attention owing to their in vitro neurotrophin potentiating activity, their in vivo and clinical efficacy trials has yet to be established.
Therefore, further research is necessary to prove the neuroprotective effects in preclinical models and in humans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Venkatesan, Ramu& Ji, Eunhee& Kim, Sun Yeou. 2015. Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review. BioMed Research International،Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1056831
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Venkatesan, Ramu…[et al.]. Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review. BioMed Research International No. 2015 (2015), pp.1-22.
https://search.emarefa.net/detail/BIM-1056831
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Venkatesan, Ramu& Ji, Eunhee& Kim, Sun Yeou. Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1056831
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056831
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر