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Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review
Joint Authors
Venkatesan, Ramu
Ji, Eunhee
Kim, Sun Yeou
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-14
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Alzheimer’s disease (AD), characterized by progressive dementia and deterioration of cognitive function, is an unsolved social and medical problem.
Age, nutrition, and toxins are the most common causes of AD.
However, currently no credible treatment is available for AD.
Traditional herbs and phytochemicals may delay its onset and slow its progression and also allow recovery by targeting multiple pathological causes by antioxidative, anti-inflammatory, and antiamyloidogenic properties.
They also regulate mitochondrial stress, apoptotic factors, free radical scavenging system, and neurotrophic factors.
Neurotrophins such as BDNF, NGF, NT3, and NT4/5 play a vital role in neuronal and nonneuronal responses to AD.
Neurotrophins depletion accelerates the progression of AD and therefore, replacing such neurotrophins may be a potential treatment for neurodegenerative disease.
Here, we review the phytochemicals that mediate the signaling pathways involved in neuroprotection specifically neurotrophin-mediated activation of Trk receptors and members of p75NTR superfamily.
We focus on representative phenolic derivatives, iridoid glycosides, terpenoids, alkaloids, and steroidal saponins as regulators of neurotrophin-mediated neuroprotection.
Although these phytochemicals have attracted attention owing to their in vitro neurotrophin potentiating activity, their in vivo and clinical efficacy trials has yet to be established.
Therefore, further research is necessary to prove the neuroprotective effects in preclinical models and in humans.
American Psychological Association (APA)
Venkatesan, Ramu& Ji, Eunhee& Kim, Sun Yeou. 2015. Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review. BioMed Research International،Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1056831
Modern Language Association (MLA)
Venkatesan, Ramu…[et al.]. Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review. BioMed Research International No. 2015 (2015), pp.1-22.
https://search.emarefa.net/detail/BIM-1056831
American Medical Association (AMA)
Venkatesan, Ramu& Ji, Eunhee& Kim, Sun Yeou. Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1056831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056831