Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction
المؤلفون المشاركون
Negi, Smita I.
Jeong, Euy-Myoung
Shukrullah, Irfan
Veleder, Emir
Fan, Tai-Hwang M.
Varadarajan, Sudhahar
Danilov, Sergei M.
Fukai, Tohru
Dudley, Samuel C.
Jones, Dean P.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Animal models have suggested a role of renin-angiotensin system (RAS) activation and subsequent cardiac oxidation in heart failure with preserved ejection fraction (HFpEF).
Nevertheless, RAS blockade has failed to show efficacy in treatment of HFpEF.
We evaluated the role of RAS activation and subsequent systemic oxidation in HFpEF.
Oxidative stress markers were compared in 50 subjects with and without early HFpEF.
Derivatives of reactive oxidative metabolites (DROMs), F2-isoprostanes (IsoPs), and ratios of oxidized to reduced glutathione ( E h GSH) and cysteine ( E h CyS) were measured.
Angiotensin converting enzyme (ACE) levels and activity were measured.
On univariate analysis, HFpEF was associated with male sex ( p = 0.04 ) , higher body mass index (BMI) ( p = 0.003 ) , less oxidized E h CyS ( p = 0.001 ) , lower DROMs ( p = 0.02 ) , and lower IsoP ( p = 0.03 ) .
Higher BMI (OR: 1.3; 95% CI: 1.1–1.6) and less oxidized E h CyS (OR: 1.2; 95% CI: 1.1–1.4) maintained associations with HFpEF on multivariate analysis.
Though ACE levels were higher in early HFpEF (OR: 1.09; 95% CI: 1.01–1.05), ACE activity was similar to that in controls.
HFpEF is not associated with significant systemic RAS activation or oxidative stress.
This may explain the failure of RAS inhibitors to alter outcomes in HFpEF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Negi, Smita I.& Jeong, Euy-Myoung& Shukrullah, Irfan& Veleder, Emir& Jones, Dean P.& Fan, Tai-Hwang M.…[et al.]. 2015. Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056883
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Negi, Smita I.…[et al.]. Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056883
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Negi, Smita I.& Jeong, Euy-Myoung& Shukrullah, Irfan& Veleder, Emir& Jones, Dean P.& Fan, Tai-Hwang M.…[et al.]. Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056883
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056883
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر