![](/images/graphics-bg.png)
Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction
Joint Authors
Negi, Smita I.
Jeong, Euy-Myoung
Shukrullah, Irfan
Veleder, Emir
Fan, Tai-Hwang M.
Varadarajan, Sudhahar
Danilov, Sergei M.
Fukai, Tohru
Dudley, Samuel C.
Jones, Dean P.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Animal models have suggested a role of renin-angiotensin system (RAS) activation and subsequent cardiac oxidation in heart failure with preserved ejection fraction (HFpEF).
Nevertheless, RAS blockade has failed to show efficacy in treatment of HFpEF.
We evaluated the role of RAS activation and subsequent systemic oxidation in HFpEF.
Oxidative stress markers were compared in 50 subjects with and without early HFpEF.
Derivatives of reactive oxidative metabolites (DROMs), F2-isoprostanes (IsoPs), and ratios of oxidized to reduced glutathione ( E h GSH) and cysteine ( E h CyS) were measured.
Angiotensin converting enzyme (ACE) levels and activity were measured.
On univariate analysis, HFpEF was associated with male sex ( p = 0.04 ) , higher body mass index (BMI) ( p = 0.003 ) , less oxidized E h CyS ( p = 0.001 ) , lower DROMs ( p = 0.02 ) , and lower IsoP ( p = 0.03 ) .
Higher BMI (OR: 1.3; 95% CI: 1.1–1.6) and less oxidized E h CyS (OR: 1.2; 95% CI: 1.1–1.4) maintained associations with HFpEF on multivariate analysis.
Though ACE levels were higher in early HFpEF (OR: 1.09; 95% CI: 1.01–1.05), ACE activity was similar to that in controls.
HFpEF is not associated with significant systemic RAS activation or oxidative stress.
This may explain the failure of RAS inhibitors to alter outcomes in HFpEF.
American Psychological Association (APA)
Negi, Smita I.& Jeong, Euy-Myoung& Shukrullah, Irfan& Veleder, Emir& Jones, Dean P.& Fan, Tai-Hwang M.…[et al.]. 2015. Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056883
Modern Language Association (MLA)
Negi, Smita I.…[et al.]. Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056883
American Medical Association (AMA)
Negi, Smita I.& Jeong, Euy-Myoung& Shukrullah, Irfan& Veleder, Emir& Jones, Dean P.& Fan, Tai-Hwang M.…[et al.]. Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056883