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Serum Soluble Adhesion Molecules and Markers of Systemic Inflammation in Elderly Diabetic Patients with Mild Cognitive Impairment and Depressive Symptoms
المؤلفون المشاركون
Gorska-Ciebiada, Malgorzata
Saryusz-Wolska, Malgorzata
Borkowska, Anna
Ciebiada, Maciej
Loba, Jerzy
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The aim of the study was to determine the serum levels of soluble adhesion molecules and hs-CRP in elderly diabetics with mild cognitive impairment (MCI) alone or with depressive symptoms.
Methods.
219 diabetics elders were screened for psychiatric disorders and divided: group 1, MCI without depressive mood; group 2, MCI with depressive mood; group 3, controls.
Data of biochemical parameters and biomarkers were collected.
Results.
In groups 1 and 2 levels of all biomarkers were significantly higher as compared to controls.
The highest level of hs-CRP and sICAM-1 was detected in group 2.
SVCAM-1 and sE-selectin levels were also the highest in group 2; however they did not significantly differ as compared to group 1.
MoCA score was negatively correlated with all biomarkers in group 1.
The logistic regression model showed that variables which increased the likelihood of having depressive syndrome in MCI patients were older age, stroke, neuropathy, increased number of comorbidities, and higher sICAM-1 level.
Conclusions.
We first demonstrated that elderly diabetic patients with MCI, particularly those with depressive mood have higher levels of soluble adhesion molecules and markers of low-grade systemic inflammation.
Coexisting depressive syndrome in patients with MCI through common inflammatory pathways may result in augmentation of psychiatric disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gorska-Ciebiada, Malgorzata& Saryusz-Wolska, Malgorzata& Borkowska, Anna& Ciebiada, Maciej& Loba, Jerzy. 2015. Serum Soluble Adhesion Molecules and Markers of Systemic Inflammation in Elderly Diabetic Patients with Mild Cognitive Impairment and Depressive Symptoms. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056891
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gorska-Ciebiada, Malgorzata…[et al.]. Serum Soluble Adhesion Molecules and Markers of Systemic Inflammation in Elderly Diabetic Patients with Mild Cognitive Impairment and Depressive Symptoms. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056891
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gorska-Ciebiada, Malgorzata& Saryusz-Wolska, Malgorzata& Borkowska, Anna& Ciebiada, Maciej& Loba, Jerzy. Serum Soluble Adhesion Molecules and Markers of Systemic Inflammation in Elderly Diabetic Patients with Mild Cognitive Impairment and Depressive Symptoms. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056891
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056891
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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