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Serum Soluble Adhesion Molecules and Markers of Systemic Inflammation in Elderly Diabetic Patients with Mild Cognitive Impairment and Depressive Symptoms
Joint Authors
Gorska-Ciebiada, Malgorzata
Saryusz-Wolska, Malgorzata
Borkowska, Anna
Ciebiada, Maciej
Loba, Jerzy
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of the study was to determine the serum levels of soluble adhesion molecules and hs-CRP in elderly diabetics with mild cognitive impairment (MCI) alone or with depressive symptoms.
Methods.
219 diabetics elders were screened for psychiatric disorders and divided: group 1, MCI without depressive mood; group 2, MCI with depressive mood; group 3, controls.
Data of biochemical parameters and biomarkers were collected.
Results.
In groups 1 and 2 levels of all biomarkers were significantly higher as compared to controls.
The highest level of hs-CRP and sICAM-1 was detected in group 2.
SVCAM-1 and sE-selectin levels were also the highest in group 2; however they did not significantly differ as compared to group 1.
MoCA score was negatively correlated with all biomarkers in group 1.
The logistic regression model showed that variables which increased the likelihood of having depressive syndrome in MCI patients were older age, stroke, neuropathy, increased number of comorbidities, and higher sICAM-1 level.
Conclusions.
We first demonstrated that elderly diabetic patients with MCI, particularly those with depressive mood have higher levels of soluble adhesion molecules and markers of low-grade systemic inflammation.
Coexisting depressive syndrome in patients with MCI through common inflammatory pathways may result in augmentation of psychiatric disorders.
American Psychological Association (APA)
Gorska-Ciebiada, Malgorzata& Saryusz-Wolska, Malgorzata& Borkowska, Anna& Ciebiada, Maciej& Loba, Jerzy. 2015. Serum Soluble Adhesion Molecules and Markers of Systemic Inflammation in Elderly Diabetic Patients with Mild Cognitive Impairment and Depressive Symptoms. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056891
Modern Language Association (MLA)
Gorska-Ciebiada, Malgorzata…[et al.]. Serum Soluble Adhesion Molecules and Markers of Systemic Inflammation in Elderly Diabetic Patients with Mild Cognitive Impairment and Depressive Symptoms. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056891
American Medical Association (AMA)
Gorska-Ciebiada, Malgorzata& Saryusz-Wolska, Malgorzata& Borkowska, Anna& Ciebiada, Maciej& Loba, Jerzy. Serum Soluble Adhesion Molecules and Markers of Systemic Inflammation in Elderly Diabetic Patients with Mild Cognitive Impairment and Depressive Symptoms. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056891