Evaluation of Novel Multiplex Antibody Kit for Human Immunodeficiency Virus 12 and Hepatitis C Virus Using Sol-Gel Based Microarray
المؤلفون المشاركون
Lim, Chae Seung
Yun, Seung Gyu
Jang, Jin Woo
Lee, Jong Han
Kim, Jinhong
Ki, Yeona
Jo, Minjoung
Kim, Soyoun
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Microarrays enable high-throughput screening (HTS) of disease-related molecules, including important signaling proteins/peptides and small molecules that are in low abundance.
In this study, we developed a multiplex blood bank screening platform, referred to as the Hi3-1 assay, for simultaneous detection of human immunodeficiency virus 1/2 (HIV 1/2) and hepatitis C virus (HCV).
Methods.
The Hi3-1 assay was tested using four panels (Panel 1, n=4,581 patient samples; Panel 2, n=15 seroconversion samples; Panel 3, n=4 performance samples; and Panel 4, n=251 purchased positive control samples), and the results were collected by the Department of Laboratory Medicine, Korea University Medical College, Republic of Korea.
The present study compares the sensitivity of the multiplex detection platform for both HIV and HCV using a sol-gel based microarray, which was based on a reference test (Architect HIV Ag/Ab Combo and Architect anti-HCV assays), in Korean patients.
Results.
The sensitivity of the multiplex detection platform for both HIV and HCV was 100%, and the specificity was 99.96% for HIV and 99.76% for HCV, which is equivalent to that of the reference test.
Conclusion.
We have successfully applied a novel screening technology to multiplex HIV and HCV diagnoses in a blood bank screening test.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yun, Seung Gyu& Jang, Jin Woo& Lee, Jong Han& Lim, Chae Seung& Kim, Jinhong& Ki, Yeona…[et al.]. 2015. Evaluation of Novel Multiplex Antibody Kit for Human Immunodeficiency Virus 12 and Hepatitis C Virus Using Sol-Gel Based Microarray. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056940
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yun, Seung Gyu…[et al.]. Evaluation of Novel Multiplex Antibody Kit for Human Immunodeficiency Virus 12 and Hepatitis C Virus Using Sol-Gel Based Microarray. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056940
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yun, Seung Gyu& Jang, Jin Woo& Lee, Jong Han& Lim, Chae Seung& Kim, Jinhong& Ki, Yeona…[et al.]. Evaluation of Novel Multiplex Antibody Kit for Human Immunodeficiency Virus 12 and Hepatitis C Virus Using Sol-Gel Based Microarray. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056940
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056940
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر