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Hypocholesterolemic Effect and In Vitro Pancreatic Lipase Inhibitory Activity of an Opuntia ficus-indica Extract
المؤلفون المشاركون
Padilla-Camberos, Eduardo
Flores-Fernández, José Miguel
Allen, Kirk
Fernandez-Flores, Ofelia
Gutierrez-Mercado, Yanet
Carmona-de la Luz, Joel
Sandoval-Salas, Fabiola
Mendez-Carreto, Carlos
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-11
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Cholesterol control is fundamental for prevention of cardiovascular disorders.
In this work, the hypocholesterolemic activity of an aqueous Opuntia ficus-indica extract (AOE) was tested in triton-induced mice.
The inhibitory activity on pancreatic lipase enzyme was evaluated in vitro by the same extract.
Furthermore, polyphenol content of the extract was evaluated.
Hypercholesterolemia was induced in three groups of mice by intraperitoneal administration of Triton WR-1339.
After induction of hypercholesterolemia, the groups were treated with an AOE (500 mg/kg) and saline solution and the positive control group with orlistat, respectively.
Cholesterol levels were measured 24 h later in peripheral blood.
The levels of blood cholesterol after administration of AOE significantly decreased compared to negative control.
The inhibitory activity of AOE on pancreatic lipase enzyme was evaluated at concentrations from 60 to 1000 μg/mL.
The AOE inhibited the pancreatic lipase with an IC50 = 588.5 μg/mL.
The AOE had a high content of polyphenolic compounds.
These results show that AOE is able to prevent hypercholesterolemia by pancreatic lipase inhibition, in part due to its polyphenolic compounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Padilla-Camberos, Eduardo& Flores-Fernández, José Miguel& Fernandez-Flores, Ofelia& Gutierrez-Mercado, Yanet& Carmona-de la Luz, Joel& Sandoval-Salas, Fabiola…[et al.]. 2015. Hypocholesterolemic Effect and In Vitro Pancreatic Lipase Inhibitory Activity of an Opuntia ficus-indica Extract. BioMed Research International،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1056941
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Padilla-Camberos, Eduardo…[et al.]. Hypocholesterolemic Effect and In Vitro Pancreatic Lipase Inhibitory Activity of an Opuntia ficus-indica Extract. BioMed Research International No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1056941
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Padilla-Camberos, Eduardo& Flores-Fernández, José Miguel& Fernandez-Flores, Ofelia& Gutierrez-Mercado, Yanet& Carmona-de la Luz, Joel& Sandoval-Salas, Fabiola…[et al.]. Hypocholesterolemic Effect and In Vitro Pancreatic Lipase Inhibitory Activity of an Opuntia ficus-indica Extract. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1056941
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056941
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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