Hypocholesterolemic Effect and In Vitro Pancreatic Lipase Inhibitory Activity of an Opuntia ficus-indica Extract
Joint Authors
Padilla-Camberos, Eduardo
Flores-Fernández, José Miguel
Allen, Kirk
Fernandez-Flores, Ofelia
Gutierrez-Mercado, Yanet
Carmona-de la Luz, Joel
Sandoval-Salas, Fabiola
Mendez-Carreto, Carlos
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Cholesterol control is fundamental for prevention of cardiovascular disorders.
In this work, the hypocholesterolemic activity of an aqueous Opuntia ficus-indica extract (AOE) was tested in triton-induced mice.
The inhibitory activity on pancreatic lipase enzyme was evaluated in vitro by the same extract.
Furthermore, polyphenol content of the extract was evaluated.
Hypercholesterolemia was induced in three groups of mice by intraperitoneal administration of Triton WR-1339.
After induction of hypercholesterolemia, the groups were treated with an AOE (500 mg/kg) and saline solution and the positive control group with orlistat, respectively.
Cholesterol levels were measured 24 h later in peripheral blood.
The levels of blood cholesterol after administration of AOE significantly decreased compared to negative control.
The inhibitory activity of AOE on pancreatic lipase enzyme was evaluated at concentrations from 60 to 1000 μg/mL.
The AOE inhibited the pancreatic lipase with an IC50 = 588.5 μg/mL.
The AOE had a high content of polyphenolic compounds.
These results show that AOE is able to prevent hypercholesterolemia by pancreatic lipase inhibition, in part due to its polyphenolic compounds.
American Psychological Association (APA)
Padilla-Camberos, Eduardo& Flores-Fernández, José Miguel& Fernandez-Flores, Ofelia& Gutierrez-Mercado, Yanet& Carmona-de la Luz, Joel& Sandoval-Salas, Fabiola…[et al.]. 2015. Hypocholesterolemic Effect and In Vitro Pancreatic Lipase Inhibitory Activity of an Opuntia ficus-indica Extract. BioMed Research International،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1056941
Modern Language Association (MLA)
Padilla-Camberos, Eduardo…[et al.]. Hypocholesterolemic Effect and In Vitro Pancreatic Lipase Inhibitory Activity of an Opuntia ficus-indica Extract. BioMed Research International No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1056941
American Medical Association (AMA)
Padilla-Camberos, Eduardo& Flores-Fernández, José Miguel& Fernandez-Flores, Ofelia& Gutierrez-Mercado, Yanet& Carmona-de la Luz, Joel& Sandoval-Salas, Fabiola…[et al.]. Hypocholesterolemic Effect and In Vitro Pancreatic Lipase Inhibitory Activity of an Opuntia ficus-indica Extract. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1056941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056941