Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study
المؤلفون المشاركون
Sirivarasai, Jintana
Chanprasertyothin, Suwannee
Kaojarern, Sukhumpun
Panpunuan, Pachara
Petchpoung, Krittaya
Tatsaneeyapant, Aninthita
Yoovathaworn, Krongtong
Sura, Thunyachai
Kaojarern, Sming
Sritara, Piyamit
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Lead has been linked to the development of hypertension via oxidative stress.
Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene.
The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project.
This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects.
Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects ( P < 0.05 ).
These significant findings are also found in MDA levels.
Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L, P < 0.05 ).
Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sirivarasai, Jintana& Kaojarern, Sukhumpun& Chanprasertyothin, Suwannee& Panpunuan, Pachara& Petchpoung, Krittaya& Tatsaneeyapant, Aninthita…[et al.]. 2015. Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057021
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sirivarasai, Jintana…[et al.]. Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057021
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sirivarasai, Jintana& Kaojarern, Sukhumpun& Chanprasertyothin, Suwannee& Panpunuan, Pachara& Petchpoung, Krittaya& Tatsaneeyapant, Aninthita…[et al.]. Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057021
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057021
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر