Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study
Joint Authors
Sirivarasai, Jintana
Chanprasertyothin, Suwannee
Kaojarern, Sukhumpun
Panpunuan, Pachara
Petchpoung, Krittaya
Tatsaneeyapant, Aninthita
Yoovathaworn, Krongtong
Sura, Thunyachai
Kaojarern, Sming
Sritara, Piyamit
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Lead has been linked to the development of hypertension via oxidative stress.
Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene.
The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project.
This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects.
Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects ( P < 0.05 ).
These significant findings are also found in MDA levels.
Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L, P < 0.05 ).
Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.
American Psychological Association (APA)
Sirivarasai, Jintana& Kaojarern, Sukhumpun& Chanprasertyothin, Suwannee& Panpunuan, Pachara& Petchpoung, Krittaya& Tatsaneeyapant, Aninthita…[et al.]. 2015. Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057021
Modern Language Association (MLA)
Sirivarasai, Jintana…[et al.]. Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057021
American Medical Association (AMA)
Sirivarasai, Jintana& Kaojarern, Sukhumpun& Chanprasertyothin, Suwannee& Panpunuan, Pachara& Petchpoung, Krittaya& Tatsaneeyapant, Aninthita…[et al.]. Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057021
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057021