Ghrelin Improves Functional Survival of Engrafted Adipose-Derived Mesenchymal Stem Cells in Ischemic Heart through PI3KAkt Signaling Pathway
المؤلفون المشاركون
Ma, Sai
Han, Dong
Huang, Wei
Chen, Jiangwei
Gao, Lina
Liu, Tong
Zhang, Rongqing
Li, Congye
Fan, Miaomiao
Chen, Yundai
Cao, Feng
Li, Xiujuan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Mesenchymal stem cells (MSCs) have been proposed as a promising cell population for cell therapy and regenerative medicine applications.
However, the low retention and poor survival of engrafted cells hampered the therapeutic efficacy of engrafted MSCs.
Ghrelin is a 28-amino-acid peptide hormone and is proved to exert a protective effect on the cardiovascular system.
This study is designed to investigate the protective effects of ghrelin on engrafted adipose-derived mesenchymal stem cells (ADMSCs) and its beneficial effects with cellular therapy in mice myocardial infarction (MI).
Results showed that intramyocardial injection of ADMSCs combining with ghrelin administration inhibited host cardiomyocyte apoptosis, reduced fibrosis, and improved cardiac function.
To reveal possible mechanisms, ADMSCs were subjected to hypoxia/serum deprivation (H/SD) injury to simulate ischemic conditions in vivo.
Ghrelin (10−8 M, 33712 pg/ml) improved ADMSCs survival under H/SD condition.
Western blot assay revealed that ghrelin increasedAKT phosphorylation both in vivo and in vitro, decreased the proapoptotic protein Bax, and increased the antiapoptotic protein Bcl-2 in vitro, while these effects were abolished by PI3K inhibitor LY294002.
These revealed that ghrelin may serve as a promising candidate for hormone-driven approaches to improve the efficacy of mesenchymal stem cell-based therapy for cardiac ischemic disease via PI3K/AKT pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Dong& Huang, Wei& Ma, Sai& Chen, Jiangwei& Gao, Lina& Liu, Tong…[et al.]. 2015. Ghrelin Improves Functional Survival of Engrafted Adipose-Derived Mesenchymal Stem Cells in Ischemic Heart through PI3KAkt Signaling Pathway. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057034
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Dong…[et al.]. Ghrelin Improves Functional Survival of Engrafted Adipose-Derived Mesenchymal Stem Cells in Ischemic Heart through PI3KAkt Signaling Pathway. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057034
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Dong& Huang, Wei& Ma, Sai& Chen, Jiangwei& Gao, Lina& Liu, Tong…[et al.]. Ghrelin Improves Functional Survival of Engrafted Adipose-Derived Mesenchymal Stem Cells in Ischemic Heart through PI3KAkt Signaling Pathway. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057034
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057034
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر