Flax Fiber Hydrophobic Extract Inhibits Human Skin Cells Inflammation and Causes Remodeling of Extracellular Matrix and Wound Closure Activation
المؤلفون المشاركون
Styrczewska, Monika
Kostyn, Anna
Kulma, Anna
Majkowska-Skrobek, Grazyna
Augustyniak, Daria
Prescha, Anna
Czuj, Tadeusz
Szopa, Jan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-04
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Inflammation is the basis of many diseases, with chronic wounds amongst them, limiting cell proliferation and tissue regeneration.
Our previous preclinical study of flax fiber applied as a wound dressing and analysis of its components impact on the fibroblast transcriptome suggested flax fiber hydrophobic extract use as an anti-inflammatory and wound healing preparation.
The extract contains cannabidiol (CBD), phytosterols, and unsaturated fatty acids, showing great promise in wound healing.
In in vitro proliferation and wound closure tests the extract activated cell migration and proliferation.
The activity of matrix metalloproteinases in skin cells was increased, suggesting activation of extracellular components remodeling.
The expression of cytokines was diminished by the extract in a cannabidiol-dependent manner, but β-sitosterol can act synergistically with CBD in inflammation inhibition.
Extracellular matrix related genes were also analyzed, considering their importance in further stages of wound healing.
The extract activated skin cell matrix remodeling, but the changes were only partially cannabidiol- and β-sitosterol-dependent.
The possible role of fatty acids also present in the extract is suggested.
The study shows the hydrophobic flax fiber components as wound healing activators, with anti-inflammatory cannabidiol acting in synergy with sterols, and migration and proliferation promoting agents, some of which still require experimental identification.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Styrczewska, Monika& Kostyn, Anna& Kulma, Anna& Majkowska-Skrobek, Grazyna& Augustyniak, Daria& Prescha, Anna…[et al.]. 2015. Flax Fiber Hydrophobic Extract Inhibits Human Skin Cells Inflammation and Causes Remodeling of Extracellular Matrix and Wound Closure Activation. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057052
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Styrczewska, Monika…[et al.]. Flax Fiber Hydrophobic Extract Inhibits Human Skin Cells Inflammation and Causes Remodeling of Extracellular Matrix and Wound Closure Activation. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1057052
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Styrczewska, Monika& Kostyn, Anna& Kulma, Anna& Majkowska-Skrobek, Grazyna& Augustyniak, Daria& Prescha, Anna…[et al.]. Flax Fiber Hydrophobic Extract Inhibits Human Skin Cells Inflammation and Causes Remodeling of Extracellular Matrix and Wound Closure Activation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057052
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057052
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر