Flax Fiber Hydrophobic Extract Inhibits Human Skin Cells Inflammation and Causes Remodeling of Extracellular Matrix and Wound Closure Activation
Joint Authors
Styrczewska, Monika
Kostyn, Anna
Kulma, Anna
Majkowska-Skrobek, Grazyna
Augustyniak, Daria
Prescha, Anna
Czuj, Tadeusz
Szopa, Jan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-04
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Inflammation is the basis of many diseases, with chronic wounds amongst them, limiting cell proliferation and tissue regeneration.
Our previous preclinical study of flax fiber applied as a wound dressing and analysis of its components impact on the fibroblast transcriptome suggested flax fiber hydrophobic extract use as an anti-inflammatory and wound healing preparation.
The extract contains cannabidiol (CBD), phytosterols, and unsaturated fatty acids, showing great promise in wound healing.
In in vitro proliferation and wound closure tests the extract activated cell migration and proliferation.
The activity of matrix metalloproteinases in skin cells was increased, suggesting activation of extracellular components remodeling.
The expression of cytokines was diminished by the extract in a cannabidiol-dependent manner, but β-sitosterol can act synergistically with CBD in inflammation inhibition.
Extracellular matrix related genes were also analyzed, considering their importance in further stages of wound healing.
The extract activated skin cell matrix remodeling, but the changes were only partially cannabidiol- and β-sitosterol-dependent.
The possible role of fatty acids also present in the extract is suggested.
The study shows the hydrophobic flax fiber components as wound healing activators, with anti-inflammatory cannabidiol acting in synergy with sterols, and migration and proliferation promoting agents, some of which still require experimental identification.
American Psychological Association (APA)
Styrczewska, Monika& Kostyn, Anna& Kulma, Anna& Majkowska-Skrobek, Grazyna& Augustyniak, Daria& Prescha, Anna…[et al.]. 2015. Flax Fiber Hydrophobic Extract Inhibits Human Skin Cells Inflammation and Causes Remodeling of Extracellular Matrix and Wound Closure Activation. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057052
Modern Language Association (MLA)
Styrczewska, Monika…[et al.]. Flax Fiber Hydrophobic Extract Inhibits Human Skin Cells Inflammation and Causes Remodeling of Extracellular Matrix and Wound Closure Activation. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1057052
American Medical Association (AMA)
Styrczewska, Monika& Kostyn, Anna& Kulma, Anna& Majkowska-Skrobek, Grazyna& Augustyniak, Daria& Prescha, Anna…[et al.]. Flax Fiber Hydrophobic Extract Inhibits Human Skin Cells Inflammation and Causes Remodeling of Extracellular Matrix and Wound Closure Activation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057052