Lipid Emulsion Attenuates Acetylcholine-Induced Relaxation in Isolated Rat Aorta
المؤلفون المشاركون
Ok, Seong-Ho
Shin, Il-Woo
Park, Jungchul
Yu, Jongsun
Lee, Youngju
Cho, Hyunhoo
Baik, Jiseok
Hong, Jeong-Min
Lee, Heon Keun
Chung, Young-Kyun
Sohn, Ju-Tae
Choi, Mun-Jeoung
Han, Jeong Yeol
Lee, Soo Hee
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We investigated the effect of Lipofundin MCT/LCT and Intralipid on acetylcholine-induced nitric oxide- (NO-) mediated relaxation in rat aorta to determine which lipid emulsion (LE) is more potent in terms of inhibition of NO-induced relaxation.
Dose-response curves of responses induced by acetylcholine, the calcium ionophore A23187, and sodium nitroprusside were generated using isolated rat aorta with or without LE.
The effect of Lipofundin MCT/LCT on acetylcholine-induced endothelial nitric oxide synthase (eNOS) phosphorylation in human umbilical vein endothelial cells (HUVECs) was investigated using western blotting.
Lipofundin MCT/LCT (0.1 and 0.2%) attenuated acetylcholine-induced relaxation in endothelium-intact aorta with or without tiron, whereas 0.2% Intralipid only inhibited relaxation.
Lipofundin MCT/LCT inhibited relaxation induced by the calcium ionophore A23187 and sodium nitroprusside in endothelium-intact aorta, but Lipofundin MCT/LCT had no effect on sodium nitroprusside-induced relaxation in the endothelium-denuded aorta.
Combined pretreatment with l-arginine plus Lipofundin MCT/LCT increased acetylcholine-induced maximal relaxation in endothelium-intact aorta compared with Lipofundin MCT/LCT alone.
l-Arginine attenuated Lipofundin MCT/LCT-mediated inhibition of acetylcholine-induced eNOS phosphorylation in HUVECs.
Taken together, Lipofundin MCT/LCT attenuated acetylcholine-induced NO-mediated relaxation via an inhibitory effect on the endothelium including eNOS, which is proximal to activation of guanylyl cyclase.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ok, Seong-Ho& Lee, Soo Hee& Yu, Jongsun& Park, Jungchul& Shin, Il-Woo& Lee, Youngju…[et al.]. 2015. Lipid Emulsion Attenuates Acetylcholine-Induced Relaxation in Isolated Rat Aorta. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057088
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ok, Seong-Ho…[et al.]. Lipid Emulsion Attenuates Acetylcholine-Induced Relaxation in Isolated Rat Aorta. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057088
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ok, Seong-Ho& Lee, Soo Hee& Yu, Jongsun& Park, Jungchul& Shin, Il-Woo& Lee, Youngju…[et al.]. Lipid Emulsion Attenuates Acetylcholine-Induced Relaxation in Isolated Rat Aorta. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057088
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057088
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر