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Effects of Low-Protein Diets Supplemented with Ketoacid on Expression of TGF-β and Its Receptors in Diabetic Rats
المؤلفون المشاركون
Yang, Xiu
Yang, Ming
Cheng, Ming
Ma, Li-Bin
Xie, Xiang-Cheng
Han, Shuai
Zhang, Bo
Fei, Xiao
Wang, Ming
Mei, Chang-Lin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
TGF-β 1 has been recognized as a key mediator in DN.
This study aimed to observe the effects of low-protein diets supplemented with ketoacid on mRNA and protein expression of TGF-β and TβRI and t TβRII receptors in the renal tissue of diabetic rats.
A diabetes model was established in 72 male SD rats.
They were then equally randomized to three groups: NPD group, LPD group, and LPD + KA group.
Additional 24 male SD rats receiving normal protein diets were used as the control.
Eight rats from each group were sacrificed at weeks 4, 8, and 12 after treatment, from which SCr, BUN, serum albumin, and 24 h urinary protein excretion were collected.
The expressions of TGF-β 1, TβRI, and TβRII in LPD and LPD + KA groups were significantly lower than those in NPD group and lower in LPD + KA group than those in LPD group.
Low-protein diets supplemented with ketoacid have been demonstrated to provide a protective effect on the renal function as represented by reduced SCr, BUN, and urinary protein excretion, probably through downregulating the gene expression of TGF-β 1 and its receptors in LPD + KA group.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Xiu& Yang, Ming& Cheng, Ming& Ma, Li-Bin& Xie, Xiang-Cheng& Han, Shuai…[et al.]. 2015. Effects of Low-Protein Diets Supplemented with Ketoacid on Expression of TGF-β and Its Receptors in Diabetic Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057097
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Xiu…[et al.]. Effects of Low-Protein Diets Supplemented with Ketoacid on Expression of TGF-β and Its Receptors in Diabetic Rats. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057097
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Xiu& Yang, Ming& Cheng, Ming& Ma, Li-Bin& Xie, Xiang-Cheng& Han, Shuai…[et al.]. Effects of Low-Protein Diets Supplemented with Ketoacid on Expression of TGF-β and Its Receptors in Diabetic Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057097
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057097
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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