Effects of Low-Protein Diets Supplemented with Ketoacid on Expression of TGF-β and Its Receptors in Diabetic Rats
Joint Authors
Yang, Xiu
Yang, Ming
Cheng, Ming
Ma, Li-Bin
Xie, Xiang-Cheng
Han, Shuai
Zhang, Bo
Fei, Xiao
Wang, Ming
Mei, Chang-Lin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
TGF-β 1 has been recognized as a key mediator in DN.
This study aimed to observe the effects of low-protein diets supplemented with ketoacid on mRNA and protein expression of TGF-β and TβRI and t TβRII receptors in the renal tissue of diabetic rats.
A diabetes model was established in 72 male SD rats.
They were then equally randomized to three groups: NPD group, LPD group, and LPD + KA group.
Additional 24 male SD rats receiving normal protein diets were used as the control.
Eight rats from each group were sacrificed at weeks 4, 8, and 12 after treatment, from which SCr, BUN, serum albumin, and 24 h urinary protein excretion were collected.
The expressions of TGF-β 1, TβRI, and TβRII in LPD and LPD + KA groups were significantly lower than those in NPD group and lower in LPD + KA group than those in LPD group.
Low-protein diets supplemented with ketoacid have been demonstrated to provide a protective effect on the renal function as represented by reduced SCr, BUN, and urinary protein excretion, probably through downregulating the gene expression of TGF-β 1 and its receptors in LPD + KA group.
American Psychological Association (APA)
Yang, Xiu& Yang, Ming& Cheng, Ming& Ma, Li-Bin& Xie, Xiang-Cheng& Han, Shuai…[et al.]. 2015. Effects of Low-Protein Diets Supplemented with Ketoacid on Expression of TGF-β and Its Receptors in Diabetic Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057097
Modern Language Association (MLA)
Yang, Xiu…[et al.]. Effects of Low-Protein Diets Supplemented with Ketoacid on Expression of TGF-β and Its Receptors in Diabetic Rats. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057097
American Medical Association (AMA)
Yang, Xiu& Yang, Ming& Cheng, Ming& Ma, Li-Bin& Xie, Xiang-Cheng& Han, Shuai…[et al.]. Effects of Low-Protein Diets Supplemented with Ketoacid on Expression of TGF-β and Its Receptors in Diabetic Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057097