Predictive Factors of Clinical Response of Infliximab Therapy in Active Nonradiographic Axial Spondyloarthritis Patients
المؤلفون المشاركون
Li, Qiuxia
Huang, Jianlin
Wei, Qiujing
Cao, Shuangyan
Liao, Zetao
Lin, Zhiming
Pan, Yunfeng
Li, Tianwang
Jin, Ou
Ai, Maixing
Wu, Henglian
Lu, Jun
Li, Li
Tang, Deshen
Wei, Yanlin
Wu, Yuqiong
Xu, Manlong
Yu, Buyun
Gu, Jieruo
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
To evaluate the efficiency and the predictive factors of clinical response of infliximab in active nonradiographic axial spondyloarthritis patients.
Methods.
Active nonradiographic patients fulfilling ESSG criteria for SpA but not fulfilling modified New York criteria were included.
All patients received infliximab treatment for 24 weeks.
The primary endpoint was ASAS20 response at weeks 12 and 24.
The abilities of baseline parameters and response at week 2 to predict ASAS20 response at weeks 12 and 24 were assessed using ROC curve and logistic regression analysis, respectively.
Results.
Of 70 axial SpA patients included, the proportions of patients achieving an ASAS20 response at weeks 2, 6, 12, and 24 were 85.7%, 88.6%, 87.1%, and 84.3%, respectively.
Baseline MRI sacroiliitis score (AUC = 0.791; P = 0.005 ), CRP (AUC = 0.75; P = 0.017 ), and ASDAS (AUC = 0.778, P = 0.007 ) significantly predicted ASAS20 response at week 12.
However, only ASDAS (AUC = 0.696, P = 0.040 ) significantly predicted ASAS20 response at week 24.
Achievement of ASAS20 response after the first infliximab infusion was a significant predictor of subsequent ASAS20 response at weeks 12 and 24 (wald χ 2 = 6.87 , P = 0.009 , and wald χ 2 = 5.171 , P = 0.023 ).
Conclusions.
Infliximab shows efficiency in active nonradiographic axial spondyloarthritis patients.
ASDAS score and first-dose response could help predicting clinical efficacy of infliximab therapy in these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Zhiming& Liao, Zetao& Huang, Jianlin& Ai, Maixing& Pan, Yunfeng& Wu, Henglian…[et al.]. 2015. Predictive Factors of Clinical Response of Infliximab Therapy in Active Nonradiographic Axial Spondyloarthritis Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057108
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Zhiming…[et al.]. Predictive Factors of Clinical Response of Infliximab Therapy in Active Nonradiographic Axial Spondyloarthritis Patients. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057108
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Zhiming& Liao, Zetao& Huang, Jianlin& Ai, Maixing& Pan, Yunfeng& Wu, Henglian…[et al.]. Predictive Factors of Clinical Response of Infliximab Therapy in Active Nonradiographic Axial Spondyloarthritis Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057108
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1057108
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر